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TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: An open label study

Published online by Cambridge University Press:  16 April 2020

Chi-Un Pae*
Affiliation:
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea Department of Psychiatry and Behavioural Sciences, Duke University, United States
Antonio Drago
Affiliation:
Institute of Psychiatry, University of Bologna, Italy
Jung-Jin Kim
Affiliation:
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
Ashwin A. Patkar
Affiliation:
Department of Psychiatry and Behavioural Sciences, Duke University, United States
Tae-Youn Jun
Affiliation:
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
Chul Lee
Affiliation:
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
Laura Mandelli
Affiliation:
Institute of Psychiatry, University of Bologna, Italy
Diana De Ronchi
Affiliation:
Institute of Psychiatry, University of Bologna, Italy
In-Ho Paik
Affiliation:
Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
Alessandro Serretti*
Affiliation:
Institute of Psychiatry, University of Bologna, Italy
*
*Corresponding author. Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, Republic of Korea. Tel.: +82 2 590 1532; fax: +82 2 536 8744. E-mail address: pae@catholic.ac.kr (C.-U. Pae), alessandro.serretti@unibo.it (A. Serretti).
**Corresponding author. Institute of Psychiatry “Paolo Ottonello”, University of Bologna, Viale Carlo Pepoli 5, 40123 Bologna, Italy. Tel.: +39 051 6584233; fax: +39 051 521030.
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Abstract

We recently reported an association between TAAR6 (trace amine associated receptor 6 gene) variations and schizophrenia (SZ). We now report an association of a set of TAAR6 variations and clinical presentation and outcome in a sample of 240 SZ Korean patients. Patients were selected by a Structured Clinical Interview, DSM-IV Axis I disorders – Clinical Version (SCID-CV). Other psychiatric or neurologic disorders, as well as medical diseases, were exclusion criteria. To assess symptom severity, patients were administered the CGI scale and the PANSS at baseline and at the moment of discharge, 1 month later on average. TAAR6 variations rs6903874, rs7452939, rs8192625 and rs4305745 were investigated; rs6903874, rs7452939 and rs8192625 entered the statistical investigation after LD analysis. Rs8192625 G/G homozygosis was found to be significantly associated both with a worse clinical presentation at PANSS total and positive scores and with a shorter period of illness before hospitalization. No haplotype significant findings were found. The present study stands for a role of the TAAR6 in the clinical presentation of SZ. Moreover, our results show that this genetic effect may be counteracted by a correct treatment. Haplotype analysis was not informative in our sample, probably also because of the incomplete SNPs' coverage of the gene we performed. Further studies in this direction are warranted.

Type
Original article
Copyright
Copyright © Elsevier Masson SAS 2008

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