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Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series

Published online by Cambridge University Press:  16 April 2020

K.N. Roy Chengappa ,
J. Levine ,
D. Rathore ,
H. Parepally  and
R. Atzert
K.N. Roy Chengappa*
Affiliation:
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA Special Studies Center at Mayview State Hospital, 1601 Mayview Road, Bridgeville, PA 15017, USA Stanley Center for the Innovative Treatment of Bipolar Disorder, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA
J. Levine
Affiliation:
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA Special Studies Center at Mayview State Hospital, 1601 Mayview Road, Bridgeville, PA 15017, USA Stanley Center for the Innovative Treatment of Bipolar Disorder, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA
D. Rathore
Affiliation:
Special Studies Center at Mayview State Hospital, 1601 Mayview Road, Bridgeville, PA 15017, USA
H. Parepally
Affiliation:
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA Special Studies Center at Mayview State Hospital, 1601 Mayview Road, Bridgeville, PA 15017, USA
R. Atzert
Affiliation:
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA Special Studies Center at Mayview State Hospital, 1601 Mayview Road, Bridgeville, PA 15017, USA
*
*Correspondence and reprints. E-mail address: chengappakn@msx.upmc.edu (K.N. Roy Chengappa).
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Summary

Topiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control.

Keywords

bipolar disorderbody mass indexdiabetes mellitustopiramateweight loss
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 3 , April 2001 , pp. 186 - 190
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2001

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