Hostname: page-component-8448b6f56d-t5pn6 Total loading time: 0 Render date: 2024-04-17T06:57:28.392Z Has data issue: false hasContentIssue false

An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population

Published online by Cambridge University Press:  16 April 2020

Yanbin Jia
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
Xin Yu
Affiliation:
Peking University Institute of Mental Health, Beijing, 100083, China
Boyu Zhang
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
Yanbo Yuan
Affiliation:
Peking University Institute of Mental Health, Beijing, 100083, China
Qi Xu
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
Yucun Shen
Affiliation:
Peking University Institute of Mental Health, Beijing, 100083, China
Yan Shen*
Affiliation:
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100005, China National Center of Human Genome Research, Beijing, 100176, China
*
* Corresponding author. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, CAMS & PUMC, 5, Dong Dan San Tiao, Beijing, 100005, China. Email address: sheny@ms.imicams.ac.cn (Y. Shen).
Get access

Abstract

We performed an association study between three SNPs in the genes of 14-3-3 family and paranoid schizophrenia. SNP rs983583 G/A in the YWHAZ gene showed significant association with paranoid schizophrenia. Our study indicated that the YWHAZ gene was a potential susceptibility gene for paranoid schizophrenia in the population studied.

Type
Rapid communication
Copyright
Copyright © 2004 European Psychiatric Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

1

These authors contributed equally to this work.

References

Berg, DHolzmann, CRiess, O. 14-3-3 proteins in the nervous system. Nat Rev Neurosci 2003;4 (9):752–62.CrossRefGoogle ScholarPubMed
Bland, JMAltman, DG. Multiple significance tests: the Bonferroni method. BMJ 1995;310 (6973):170.CrossRefGoogle ScholarPubMed
Blouin, JLDombroski, BANath, SKLasseter, VKWolyniec, PSNestadt, G, et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet 1998;20(1):70–3.CrossRefGoogle ScholarPubMed
Cichon, SSchumacher, JMuller, DJHurter, MWindemuth, CStrauch, K, et al. A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q. Hum Mol Genet 2001;10(25):2933–44.CrossRefGoogle ScholarPubMed
Lewis, CMLevinson, DFWise, LHDeLisi, LEStraub, REHovatta, I, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, Part II: Schizophrenia. Am J Hum Genet 2003;73(1):34–48.CrossRefGoogle ScholarPubMed
Moller, HJ. Bipolar disorder and schizophrenia: distinct illnesses or a continuum? J Clin Psychiatry 2003;64(Suppl 6):23–7.Google ScholarPubMed
Waddington, JL. Schizophrenia: developmental neuroscience and pathobiology. Lancet 1993;341 (8844):531–6.CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.