Hostname: page-component-7c8c6479df-hgkh8 Total loading time: 0 Render date: 2024-03-28T15:54:26.103Z Has data issue: false hasContentIssue false

945 – Association Study Between The c3435t Polymorphism Of The Multidrug Resistance 1 (mdr1) And Interpersonal Sensitivity

Published online by Cambridge University Press:  15 April 2020

E. Masanori
Affiliation:
Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
A. Suzuki
Affiliation:
Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
R. Sadahiro
Affiliation:
Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
Y. Matsumoto
Affiliation:
Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
N. Shibuya
Affiliation:
Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
M. Kamata
Affiliation:
Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
K. Otani
Affiliation:
Psychiatry, Yamagata University School of Medicine, Yamagata, Japan

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

P-glycoprotein, which is encoded by the multidrug resistance 1 (MDR1) gene, serves as a barrier to entry and as an active elimination for xenobiotics and cellular metabolites including cortisol, which is implicated in multiple brain functions. Meanwhile, previous studies suggested that genetic factors and cortisol are involved in formation of interpersonal sensitivity, a personality trait predisposing to depression. In the present study, we examined the effects of the C3435T MDR1 polymorphism on interpersonal sensitivity. The subjects were 842 healthy Japanese volunteers. The mean age ±SD of the subjects was 26.7±8.1 (490 males and 352 females). The C3435T polymorphism of MDR1 gene was detected by a PCR method, and interpersonal sensitivity was assessed by the Interpersonal Sensitivity Measure (IPSM). In total subjects, the C allele of the C3435T MDR1 polymorphism was associated with higher scores of the IPSM. In females the C/C genotype group had higher IPSM scores than the C/T genotype group and the T/T genotype group, and the C/T genotype group had higher IPSM scores than the T/T genotype group. In males no significant association was found between the MDR1 genotype and the IPSM scores. The present study suggests that the C3435T polymorphism of the MDR1 gene affects formation of a depression-prone personality trait in Japanese females.

Type
Abstract
Copyright
Copyright © European Psychiatric Association 2013
Submit a response

Comments

No Comments have been published for this article.