Hostname: page-component-7479d7b7d-t6hkb Total loading time: 0 Render date: 2024-07-12T02:03:32.811Z Has data issue: false hasContentIssue false

1965 – Corticosteroid-induced Mania Treated With Risperidone - a Case Report

Published online by Cambridge University Press:  15 April 2020

T. Almeida
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal
F. Araújo
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal
J.D. Rodrigues
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal
Â. Venâncio
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal
A. Horta
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal
A.L. Monteiro
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal
G. Lapa
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal
J. Bouça
Affiliation:
Department of Psychiatry and Mental Health Vila Nova de Gaia/Espinho Healthcare Center, Vila Nova de Gaia, Portugal

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Corticosteroids have either somatic and psychiatric side effects. Somatic adverse effects are well described while neuropsychiatric have received less attention. Psychiatric symptoms such as depression, psychosis and especially mania are common side effects of corticotherapy.

Aims and objectives

Describe a case of a 53 year old female patient, with no psychiatric history, who developed psychiatric symptoms during the treatment of an acute exacerbation of multiple sclerosis with large parenteral doses of corticosteroids. Three days after the onset of corticotherapy she developed increased energy, elevated mood, increased motor activity, racing thoughts, and diminished need for sleep. She subsequently developed grandiose and persecutory ideation and then feared her grandson was going to die. This lead to her admission to psychiatric unit of our hospital to address this behavioral problems. Her husband noticed that she had become “hyper” in the past when she received pulse corticosteroid therapy, but the most recent episode was by far the worst.

Methods

Revision of the scientific literature through Pubmed, Embase and Psychinfo using search terms including corticosteroids, mania, depression, psychosis and mood.

Results

Prednisone was suspended and Risperidone 2 mg was begun for presumed steroid-induced mood disorder, and the patient became calmer and much less guarded over the next 2-3 days. After a week she recovered complete euthymic mood and reverted to normal functioning.

Conclusions

These data suggest that Risperidone is well tolerated and appears to be useful for mood disturbances associated with corticosteroid therapy. Controlled trials seem warranted to confirm these observations.

Type
Abstract
Copyright
Copyright © European Psychiatric Association 2013
Submit a response

Comments

No Comments have been published for this article.