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1816 – Prenatal Exposure To Lithium And Fetal And Neonatal Growth

Published online by Cambridge University Press:  15 April 2020

M.L. Imaz ,
E. Eixarch ,
A. Torres ,
A. González-Rodríguez ,
R. García-Bouza ,
G. Español ,
E. Roda ,
F. Botet ,
F. Figueras  and
L. García-Esteve
M.L. Imaz
Affiliation:
Perinatal Psychiatry and Gender Research Program, Department of Psychiatry and Psychology, Institut Clínic of Neuroscience, Hospital Clínic Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona
E. Eixarch
Affiliation:
Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona Department of Maternal-Fetal Medicine, Institut Clínic of Gynaecology, Osbtetrics and Neonatology, Hospital Clínic, Barcelona
A. Torres
Affiliation:
Perinatal Psychiatry and Gender Research Program, Department of Psychiatry and Psychology, Institut Clínic of Neuroscience, Hospital Clínic Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona
A. González-Rodríguez
Affiliation:
Perinatal Psychiatry and Gender Research Program, Department of Psychiatry and Psychology, Institut Clínic of Neuroscience, Hospital Clínic
R. García-Bouza
Affiliation:
Psychiatry, University Hospital of Elche, Alicante
G. Español
Affiliation:
Psychiatry, Corsorci Sanitari Terrasa, Hospital Clínic, Barcelona, Spain
E. Roda
Affiliation:
Perinatal Psychiatry and Gender Research Program, Department of Psychiatry and Psychology, Institut Clínic of Neuroscience, Hospital Clínic
F. Botet
Affiliation:
Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona Neonatology, Institut Clínic of Gynaecology, Osbtetrics and Neonatology, Hospital Clínic, Barcelona, Spain
F. Figueras
Affiliation:
Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona Department of Maternal-Fetal Medicine, Institut Clínic of Gynaecology, Osbtetrics and Neonatology, Hospital Clínic, Barcelona
L. García-Esteve
Affiliation:
Perinatal Psychiatry and Gender Research Program, Department of Psychiatry and Psychology, Institut Clínic of Neuroscience, Hospital Clínic Institut d’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona

Abstract

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Introduction

Insulin-dependent diabetes, obesity and gestational diabetes are factors associated with macrosomia. Some psychiatric medications have well established side effects of weight changes in exposed pregnants. However, very few studies have investigated about the effects of lithium in fetal and neonatal anthropometry.

Aims

To investigate the effects of maternal use of lithium during pregnancy on fetal and neonatal growth.

Methods

A case-control study was conducted at the PERINATAL PSYCHIATRY PROGRAM CLÍNIC-BARCELONA. Case group consisted of 18 pregnant women on maintenance treatment with lithium monotherapy (n=13) or polytherapy (n=5) during pregnancy; control group involves 49 healthy women selected from an initial sample of 309. We evaluated sociodemographic data, lithium plasma concentrations in maternal blood and umbilical cord, fetal and neonatal anthropometry.

Results

Women did not diabetes or obesity criteria pre-pregnancy and during pregnancy. Mean maternal age (SD) in lithium exposed cases was 33.5 (3.8) and 32.5 (4.1) in non-exposed pregnant. No statistically significant differences were found regarding sociodemographic variables and pre-pregnancy BMI. Caesarean section was required in 91.8% of lithium exposed mothers, whereas 8.2% of non-exposed women did not need it (p= 0.000). Fetuses exposed to lithium had greater abdominal circumference (p= 0.018) and femur length (p= 0.010) compared to non-exposed group. There were no differences in umbilical cord/maternal plasma lithium ratio between women treated with lithium monotherapy or polytherapy (1.11vs.1.03).

Conclusions

The fetuses exposed to lithium had a greater abdominal circumference, greater femur length and more caesarean section in comparison to non-exposed group. Fetal growth surveillance is recommended in pregnant treated with lithium.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1069
Copyright
Copyright © European Psychiatric Association 2013
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