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1725 – Using Home Recruitment To Increase Representativeness Of Schizophrenia Research

Published online by Cambridge University Press:  15 April 2020

M. Haapea
Affiliation:
Department of Psychiatry, Oulu, Finland Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
M. Isohanni
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
E. Jääskeläinen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
J. Veijola
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland
J. Miettunen
Affiliation:
Department of Psychiatry, University of Oulu, Oulu, Finland

Abstract

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Introduction

The participation rates in epidemiologic studies have declined in recent decades. Missing data reduce sample size, statistical power, and scientific quality.

Objective

To study use of home interviews in recruiting individuals with a psychosis.

Aims

To evaluate effect of home-recruitment on non-response bias.

Methods

In the Northern Finland 1966 Birth Cohort, field surveys on psychosis were conducted in 1999-2001 and 2008-2010. In order to increase participation in the follow-up sample, cases were offered to be interviewed at home. We studied symptoms, illness severity, functioning, cognition, antipsychotics use, and grey matter (GM) volume between home-recruited and regular participants (RP), and non-participants (NP). Effect sizes (d) were calculated to compare the differences.

Results

Altogether 18 (33%) out of the follow-up sample (n=54) were home-recruited, 27 did not participate. Home-recruited had more symptoms, lower functioning, cognition and GM volume, and they had used more antipsychotics compared to RP and NP in baseline. NP did not differ from RP. The same differences occurred when home-recruited were compared with RP in the follow-up study.

[Selected information from baseline study]

 Homerecruited participantsRegular participantsNonparticipantsANOVA  
 Mean (SD)Mean (SD)Mean (SD)Pd1d2
PANSS, negative19 (11)12 (6)14 (10)0.0280.890.48
PANSS, disorganization21 (9)15 (7)16 (9)0.0330.810.60
PANSS, excitement13 (5)10 (2)12 (5)0.0250.910.38
SOFAS40 (19)57 (15)54 (15)0.002-1.04-0.85
CVLT, total recall39 (14)51 (13)44 (16)0.032-0.89-0.30
Dose years44 (47)15 (18)12 (13)0.0020.921.00
Grey matter volume593 (60)642 (64)623 (61)0.039-0.77-0.49

Conclusion

Owing to the home-recruitment we were able to collect data that may be reasonably non-biased in terms of nonresponse bias, which will yield valid estimates in our future studies on change over time in brain and cognitive ability, prevalence and severity of psychotic illnesses, outcome, medication use, and other issues of interest.

Type
Abstract
Copyright
Copyright © European Psychiatric Association 2013
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