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1380 – Association Of Polymorphism Og Genes Neuromediator System Of The Brain (drd4, Dat) With Depression In Siberia

Published online by Cambridge University Press:  15 April 2020

V. Gafarov ,
E. Gromova ,
I. Gagulin ,
A. Gafarova ,
V. Maximov  and
M. Voevoda
V. Gafarov
Affiliation:
Institute of Internal Medicine SB RAMS Collaborative Laboratory of Epidemiology of Cardiovascular Disease SB RAMS, Novosibirsk, Russia
E. Gromova
Affiliation:
Institute of Internal Medicine SB RAMS Collaborative Laboratory of Epidemiology of Cardiovascular Disease SB RAMS, Novosibirsk, Russia
I. Gagulin
Affiliation:
Institute of Internal Medicine SB RAMS Collaborative Laboratory of Epidemiology of Cardiovascular Disease SB RAMS, Novosibirsk, Russia
A. Gafarova
Affiliation:
Institute of Internal Medicine SB RAMS Collaborative Laboratory of Epidemiology of Cardiovascular Disease SB RAMS, Novosibirsk, Russia
V. Maximov
Affiliation:
Institute of Internal Medicine SB RAMS
M. Voevoda
Affiliation:
Institute of Internal Medicine SB RAMS

Abstract

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As part of WHO «MONICA» in 1994, surveyed a random representative sample of men aged 25-64 years, residents of one of the areas of Novosibirsk (657 men). Depression was determined using a questionnaire of the WHO program «MONICApsychosocial ». It was genotyped the investigated polymorphisms of genes DRD4, DAT. Men in the open population of Novosibirsk, high levels of depression (29%). Since depression was significantly associated genotype 4 / 6 of the DRD4 gene and genotype 9 / 9 gene DAT. Accordingly, the depression significantly associated allele of the DRD4 gene and 6 allele of the gene 9 DAT.

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Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E713
Copyright
Copyright © European Psychiatric Association 2013
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