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1344 – PDYN Rs2281285 Variant Is Associated With Alcohol Dependence In Male But Not Female Subjects

Published online by Cambridge University Press:  15 April 2020

V.M. Karpyak ,
S.J. Winham ,
U.W. Preuss ,
P. Zill ,
J.M. Cunningham ,
D.L. Walker ,
J.R. Geske ,
C.L. Colby ,
O.A. Abulseoud  and
D.K. Hall-Flavin
...Show all authors
V.M. Karpyak
Affiliation:
Psychiatry and Psychology
S.J. Winham
Affiliation:
Health Sciences Research, Mayo Clinic, Rochester, MN, USA
U.W. Preuss
Affiliation:
Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University of Halle-Wittenberg, Halle/Saale
P. Zill
Affiliation:
Psychiatry, Section of Psychiatric Genetics and Neurochemistry, LMU Munich, Munich, Germany
J.M. Cunningham
Affiliation:
Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
D.L. Walker
Affiliation:
Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
J.R. Geske
Affiliation:
Health Sciences Research, Mayo Clinic, Rochester, MN, USA
C.L. Colby
Affiliation:
Health Sciences Research, Mayo Clinic, Rochester, MN, USA
O.A. Abulseoud
Affiliation:
Psychiatry and Psychology
D.K. Hall-Flavin
Affiliation:
Psychiatry and Psychology
L.L. Loukianova
Affiliation:
Psychiatry and Psychology
T.D. Schneekloth
Affiliation:
Psychiatry and Psychology
M.A. Frye
Affiliation:
Psychiatry and Psychology
I. Bazov
Affiliation:
Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
J.A. Heit
Affiliation:
Internal Medicine, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
G. Bakalkin
Affiliation:
Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
D.A. Mrazek
Affiliation:
Psychiatry and Psychology
J.M. Biernacka
Affiliation:
Health Sciences Research, Mayo Clinic, Rochester, MN, USA

Abstract

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Introduction

Recent findings support sex-specific effects of PDYN polymorphisms on association with opioid addiction (Clarke et al. 2012). We have demonstrated that PDYN haplotypes, which include rs2281285, are associated with alcohol dependence and propensity to drink in negative emotional situations (negative craving) (Karpyak et al 2012). The rs2281285 variant may contribute to regulation of alternative PDYN mRNA transcription specific to brain area or physiological condition.

Objectives

To investigate sex-specific effects of the PDYN rs2281285 variant on risk for alcohol dependence.

Aims

To examine the association of the PDYN rs2281285 variant with alcohol dependence in male and female subjects.

Methods

rs2281285 was genotyped in the investigation cohort of 816 (554 males) alcohol dependent subjects (DSM-IV-TR) and 1248 (603 males) non-alcoholic controls and in the replication cohort of 467 (347 males) alcohol dependent subjects and 431 (224 males) non-alcoholic controls. Logistic regression models were used to test for sex-specific associations after controlling for age.

Results

As previously reported, significant association of the PDYN rs2281285 variant with alcohol dependence was found in the investigation (p = 0.008, odds ratio = 1.299), but not the replication cohort (0.223, OR = 0.118). However, sex-specific analyses revealed stronger association in males (p = 0.002, OR = 1.493) but not females (p = 0.684, OR = 1.066) in the investigation cohort, and a trend for association in males (p = 0.086, OR = 1.352) but not females (p = 0.808, OR = 0.947) in the replication cohort.

Conclusions

Our findings support association of PDYN rs2281285 variant with alcohol dependence in male but not female subjects. Future studies should investigate functional mechanisms of this effect.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E680
Copyright
Copyright © European Psychiatric Association 2013
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