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¿Hay una asociación entre el gen de la COMT y los endofenotipos de la onda P300?

Published online by Cambridge University Press:  12 May 2020

E. Bramon ,
E. Dempster ,
S. Frangou ,
C. McDonald ,
P. Schoenberg ,
J.H. MacCabe ,
M. Walshe ,
P. Sham ,
D. Collier  and
R.M. Murray
E. Bramon
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
E. Dempster
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
S. Frangou
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
C. McDonald
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
P. Schoenberg
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
J.H. MacCabe
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
M. Walshe
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
P. Sham
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
D. Collier
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
R.M. Murray
Affiliation:
Instituto de Psiquiatria, King 's College London, De Crespigny Park, Londres SE5 8AF, Reino Unido
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Resumen

Las anomalías de la onda P300 correlacionan con el riesgo genético de esquizofrenia y constituyen un enfofenotipo plausible para la enfermedad. Se piensa que el gen de la COMT influye en la ejecución cognitiva y es un gen de susceptibilidad para la esquizofrenia. A diferencia de dos estudios anteriores, no encontramos influencia significativa del gen de la COMT en la amplitud o la latencia de la onda P300 en 189 individuos examinados. El papel bien respaldado del gen de la COMT tanto en el catabolismo de la dopamina como en la cognición prefrontal constituye un fuerte argumento teórico para la influencia del polimorfismo Val158Met de la COMT en los endofenotipos de la onda P300. Sin embargo, los datos neurofisiológicos disponibles indican que cualquier asociación de esta índole, si está presente, debe ser muy sutil.

Keywords

NeurofisiologíaEsquizofreniaMarcador biológicoEndofenotipoonda P300gen de la COMT
Type
Original
Information
European Psychiatry (Ed. Española) , Volume 13 , Issue 5 , June 2006 , pp. 244 - 248
Copyright
Copyright © European Psychiatric Association 2006

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