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Funciones neuroendocrinas e inmunológicas en pacientes deprimidos: un estudio de seguimiento

Published online by Cambridge University Press:  12 May 2020

S. Cervera-Enguix  and
Ȧ. Rodríguez-Rosado
S. Cervera-Enguix
Affiliation:
Facultad de Medicina, Universidad de Navarra y Departamento de Psiquiatría y Psicología Médica, Hospital Universitario de la Universidad de Navarra
Ȧ. Rodríguez-Rosado
Affiliation:
Hospital Universitario de la Universidad de Navarra, Pamplona (Navarra), España
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Resumen

El desarrollo, valoración y uso de marcadores biológicos con un propósito diagnóstico en psiquiatría es sumamente importante. Sin embargo, con ciertas excepciones, todavía no han surgido marcadores verdaderamente sensibles y específicos. Para investigar la relación entre el aparato inmune y la actividad hipotalámico-pituitaria por una parte, y el estado psicopatológico de los pacientes por otra, utilizamos un diseño longitudinal y evaluamos parámetros de monocitos (HLA-DR, CD 35, filamentos de vimentín e índice de fagocitosis) y pruebas neuroendocrinas (prueba de supresión con dexametasona [DST] y prueba de estimulación de la hormona liberadora de tirotropina [TRH]) en la admisión y en el seguimiento en 49 pacientes deprimidos. Se compararon parámetros inmunológicos con pruebas neuroendocrinas en ambas fases del estudio. El uso combinado de pruebas inmunológicas y neuroendocrinas no añadió sensibilidad a la identificación inmunológica de los pacientes deprimidos. Los hallazgos nos llevaron a considerar el papel de los parámetros de monocitos como marcadores sensibles del estado depresivo, mientras que el uso combinado de pruebas neuroendocrinas e inmunológicas en la práctica clínica actual sería discutible.

Keywords

depresiónDSTprueba de TSHdisfunción de monocitos
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 2 , Issue 3 , June 1995 , pp. 191 - 199
Copyright
Copyright © European Psychiatric Association 1995

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