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Estudio prospectivo del volumen y la función del hipocampo en sujetos humanos tratados con corticoesteroides

Published online by Cambridge University Press:  12 May 2020

Tomáš Hájek ,
Miloslav Kopeček ,
Marek Preiss ,
Martin Alda  and
Cyril Höschl
Tomáš Hájek
Affiliation:
Centro Psiquiátrico de Praga y Universidad Carlos, 3a Facultad de Medicina, Praga, República Checa Departamento de Psiquiatría, Universidad Dalhousie, QEII HSC, A. J. Lane Bldg., Habitación4031, 5909 Veteran's Memorial Lane, Halifax, NS, Canadá B3H 2E2
Miloslav Kopeček
Affiliation:
Centro Psiquiátrico de Praga y Universidad Carlos, 3a Facultad de Medicina, Praga, República Checa
Marek Preiss
Affiliation:
Centro Psiquiátrico de Praga y Universidad Carlos, 3a Facultad de Medicina, Praga, República Checa
Martin Alda
Affiliation:
Centro Psiquiátrico de Praga y Universidad Carlos, 3a Facultad de Medicina, Praga, República Checa Departamento de Psiquiatría, Universidad Dalhousie, QEII HSC, A. J. Lane Bldg., Habitación4031, 5909 Veteran's Memorial Lane, Halifax, NS, Canadá B3H 2E2
Cyril Höschl
Affiliation:
Centro Psiquiátrico de Praga y Universidad Carlos, 3a Facultad de Medicina, Praga, República Checa
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Resumen

Propósito.

La disminución del volumen del hipocampo comunicada en trastornos neuropsiquiátricos y endocrinos se considera resultado de un daño neuronal putativo mediado por corticoesteroides. Éste es el primer estudio prospectivo del volumen y la función del hipocampo en pacientes tratados con corticoesteroides.

Métodos.

Se sometió a 14 sujetos tratados sistémicamente con prednisona o betametasona por trastornos dermatológicos o reumáticos a pruebas neurocognitivas prospectivas (Prueba de Aprendizaje Verbal Auditivo [AVLT], Prueba del Trazo [TMT], Amplitud de dígitos [AD]) y nueve de ellos repitieron también una volumetría de resonancia magnética.

Resultados.

La duración media del tratamiento entre la primera evaluación y la segunda fue 73 ± 38 días con dosis diaria media de 37 ± 17 mg de prednisona y 193 ± 29 días, con dosis diaria media de 24 ± 15 mg de prednisona, entre la primera evaluación y la tercera. Hubo una tendencia a disminuciones en las puntuaciones totales de la AVLT y una mejoría en la TMT y la AD, pero ausencia de cambios significativos en el volumen de los hipocampos derecho o izquierdo entre las evaluaciones. La dosis de prednisona no correlacionaba con el cambio de volumen del hipocampo.

Conclusión.

Observamos una tendencia a la disminución en la memoria verbal a pesar de la mejora en la velocidad psicomotriz, la atención/memoria operativa y una ausencia de cambios del volumen macroscópico del hipocampo durante los 36-238 días de tratamiento con dosis terapéuticas de corticoesteroides.

Keywords

HipocampoCorticoesteroidesImágenes de resonancia magnéticaMemoria
Type
Original
Information
European Psychiatry (Ed. Española) , Volume 13 , Issue 6 , September 2006 , pp. 295 - 300
Copyright
Copyright © European Psychiatric Association 2006

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