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On an approximate method of determining the median effective dose and its error, in the case of a quantal response

Published online by Cambridge University Press:  15 May 2009

J. O. Irwin  and
E. A. Cheeseman
J. O. Irwin
Affiliation:
Of the Medical Research Council's Statistical Staff From the Division of Epidemiology and Vital Statistics, London School of Hygiene and Tropical Medicine
E. A. Cheeseman
Affiliation:
Of the Medical Research Council's Statistical Staff From the Division of Epidemiology and Vital Statistics, London School of Hygiene and Tropical Medicine
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Käber's method is, for many purposes, a sufficiently accurate way of determining the median effective dose, when we have a series of doses increasing in a constant ratio and a small number of animals on each. The standard error of the determination may also be rapidly found by a simple approximate method. Illustrative examples are given.

The standard error calculated by the approximate method is based on the assumption that the animals are homogeneous. It must be used with caution when any heterogeneity is suspected. With animals of similar heterogeneity to those used here, the differences between two different toxic-fractions should only be regarded as significant if they are from 3 to 3.5 times their standard errors so calculated.

Type
Research Article
Information
Journal of Hygiene , Volume 39 , Issue 5 , September 1939 , pp. 574 - 580
Copyright
Copyright © Cambridge University Press 1939

References

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