Some 40 brachiopod species are known from the localities of Kilbucho and Wallace’s Cast in the Kirkcolm Formation in the Northern Belt of the Southern Uplands of Scotland. The fauna is diverse despite the relatively small numbers of brachiopod specimens (c. 180) available for study. Much of the fauna was transported downslope and is locally preserved in obtrution deposits. It represents a broad census of outer shelf and upper slope palaeocommunities around this part of the Laurentian margin during the early Katian, and is dominated by relatively small plectambonitoid brachiopods. When compared with other circum-Iapetus assemblages, the brachiopods from the Southern Uplands compare most closely with those from the Bardahessiagh Formation, Pomeroy, Northern Ireland, rather than with adjacent, well-known faunas from the Girvan district, SW Scotland. These new data suggest that this part of the Southern Uplands was located in closer proximity to Pomeroy than Girvan, and located in deep-water environments similar to those in the upper parts of the Bardahessiagh Formation.