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Changes in Polyploidy During Aging in Human Liver

Published online by Cambridge University Press:  29 November 2010

Hildegard E. Enesco ,
Marie I. Laskey  and
Michael Fisman
Hildegard E. Enesco
Affiliation:
Concordia University
Marie I. Laskey
Affiliation:
Concordia University
Michael Fisman
Affiliation:
London Psychiatric Hospital
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Abstract

The level of liver polyploidy was compared in three groups of humans: a young group aged 20–46, an older group aged 62–68 and the oldest group aged 70–79. The most important trend showed by the data was that there is a depletion of 2N and 4N cells, accompanied by an increase in 8N and 16N cells as a function of advancing age. There was a high degree of variability in the percentage of cells in each ploidy class from one individual to the next for all age groups. For this reason, polyploidy appears to be a less effective biomarker of aging in humans than it is in experimental animals.

Résumé

Différentes classes de noyaux polyploides, mesurés, dans le foie, sont étudiés chez des humains répartis en 3 groupes: 20–46 ans; 62–68 ans, et 70–79 ans. Malgré la grande variabilité du degré de la polyploidie entre les membres de chaque groupe, les mesures indiquent que chez les personnes plus agées, on peut distinguer deux tendances; d'une part, une réduction du pourcentage des diploides et de tetraploides et d'autre part, une augmentation des octoploides et des noyaux 16 N.

Keywords

liverpolyploidyaging changes
Type
Articles
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 5 , Issue 4 , Winter/L'hiver 1986 , pp. 249 - 255
Copyright
Copyright © Canadian Association on Gerontology 1986

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