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The Usefulness of CT Scanning in Diagnosing Dementia of the Alzheimer Type

Published online by Cambridge University Press:  18 September 2015

J. Willmer ,
A. Carruthers ,
D.A. Guzman ,
B. Collins ,
J. Pogue  and
D.T. Stuss
J. Willmer*
Affiliation:
Elisabeth Bruyère Health Centre, Department of Medicine (Neurology), University of Ottawa (J.W., A.C., D.A.G.); Department of Psychology, Ottawa General Hospital (B.C.); Rotman Research Institute of Baycrest Centre for Geriatric Care (J.P., D.T.S.) and Division of Neurology and Department of Psychology, University of Toronto (D.T.S.)
A. Carruthers*
Affiliation:
Elisabeth Bruyère Health Centre, Department of Medicine (Neurology), University of Ottawa (J.W., A.C., D.A.G.); Department of Psychology, Ottawa General Hospital (B.C.); Rotman Research Institute of Baycrest Centre for Geriatric Care (J.P., D.T.S.) and Division of Neurology and Department of Psychology, University of Toronto (D.T.S.)
D.A. Guzman*
Affiliation:
Elisabeth Bruyère Health Centre, Department of Medicine (Neurology), University of Ottawa (J.W., A.C., D.A.G.); Department of Psychology, Ottawa General Hospital (B.C.); Rotman Research Institute of Baycrest Centre for Geriatric Care (J.P., D.T.S.) and Division of Neurology and Department of Psychology, University of Toronto (D.T.S.)
B. Collins*
Affiliation:
Elisabeth Bruyère Health Centre, Department of Medicine (Neurology), University of Ottawa (J.W., A.C., D.A.G.); Department of Psychology, Ottawa General Hospital (B.C.); Rotman Research Institute of Baycrest Centre for Geriatric Care (J.P., D.T.S.) and Division of Neurology and Department of Psychology, University of Toronto (D.T.S.)
J. Pogue*
Affiliation:
Elisabeth Bruyère Health Centre, Department of Medicine (Neurology), University of Ottawa (J.W., A.C., D.A.G.); Department of Psychology, Ottawa General Hospital (B.C.); Rotman Research Institute of Baycrest Centre for Geriatric Care (J.P., D.T.S.) and Division of Neurology and Department of Psychology, University of Toronto (D.T.S.)
D.T. Stuss*
Affiliation:
Elisabeth Bruyère Health Centre, Department of Medicine (Neurology), University of Ottawa (J.W., A.C., D.A.G.); Department of Psychology, Ottawa General Hospital (B.C.); Rotman Research Institute of Baycrest Centre for Geriatric Care (J.P., D.T.S.) and Division of Neurology and Department of Psychology, University of Toronto (D.T.S.)
*
Elisabeth Bruyère Health Centre, 75 Bruyère Street, Ottawa, Ontario, Canada KIN 5C8
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Abstract:

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In order to determine the usefulness of Computerized Tomography (CT) scanning in making a diagnosis of dementia of the Alzheimer type, a group of patients diagnosed by NINCDS - ADRDA criteria (n = 22) were compared to a group of normal subjects (n = 49) using certain defined linear CT scan measurements. These measurements included specific measurements of the temporal lobes (temporal horns). Subjects were classified correctly 91.5% of the time with a high degree of probability. A diagnostic equation is presented which will allow testing of these methods in a prospective fashion.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 3 , August 1993 , pp. 210 - 216
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Benson, DF. Neuroimaging and dementia. Neurol Clin 1986; 4(2): 341–353.CrossRefGoogle ScholarPubMed
2.Bradshaw, JR, Thomson, JL, Campbell, MJ. Computed tomography in the investigation of dementia. Br Med J (Clin Res Ed) 1983; 286(6361): 277–280.CrossRefGoogle ScholarPubMed
3.Jagust, WJ, Eberling, JL. MRI, CT, SPECT, PET: their use in diagnosing dementia. Geriatrics 1991 Feb; 46(2): 28–35.Google ScholarPubMed
4.Petrie, WM. Alzheimer's disease. Compr Ther 1985; 11(7): 38–43.Google ScholarPubMed
5.Katzman, R. Clinical presentation of the course of Alzheimer's disease: the atypical patient. Interdisciplin Top Gerontol 1985: 20: 12–18.CrossRefGoogle Scholar
6.Tomlinson, BE, Blessed, G, Roth, M. Observations on the brains of demented old people. J Neurol Sci 1970; 11(3): 205–242.Google Scholar
7.Huckman, MS, Fox, J, Topel, J. The validity of criteria for the evaluation of cerebral atrophy by computed tomography. Radiology 1975; 116(1): 85–92.CrossRefGoogle ScholarPubMed
8.Tomlinson, BE. Blessed, G, Roth, M. Observations on the brains of non-demented old people. J Neurol Sci 1968; 7(2): 331–356.CrossRefGoogle ScholarPubMed
9.Laffey, PA, Peyster, RG, Nathan, R, Haskin, ME. McGinley, JA. Computed tomography and aging: results in a normal elderly population. Neuroradiology 1984; 26(4): 273–278.CrossRefGoogle Scholar
10.Ford, CV, Winter, J. Computerized axial tomograms and dementia in elderly patients. J Gerontol 1981: 36(2): 164–169.CrossRefGoogle ScholarPubMed
11.Hughes, CP, Gado, M. Computed tomography and aging of the brain. Radiology 1981; 139(2): 391–396.CrossRefGoogle ScholarPubMed
12.Gado, M, Hughes, CP, Danziger, W, Chi, D. Aging, dementia, and brain atrophy: a longitudinal computed tomographic study. Am J Neuroradiol 1983; 4(3): 699–702.Google ScholarPubMed
13.George, AE, de, Leon MJ, Rosenbloom, S, Ferris, SH, Gentes, C, et al.Ventricular volume and cognitive deficit: a computed tomographic study. Radiology 1983; 149(2): 493–498.CrossRefGoogle ScholarPubMed
14.Roberts, MA, Caird, Fl, Grossart, KW, Steven, JL. Computerized tomography in the diagnosis of cerebral atrophy. J Neurol Neurosurg Psychiatry 1976; 39(9): 909–915.CrossRefGoogle ScholarPubMed
15.McGeer, PL. Brain imaging in Alzheimer's disease. Br Med Bull 1986; 42(1): 24–28.CrossRefGoogle ScholarPubMed
16.de, Leon MJ, George, AE. Reisberg, B, Ferris, SH, Kluger, A. et al.Alzheimer's disease: longitudinal CT studies of ventricular change. Am J Radiol 1989; 152(6): 1257–1262.Google Scholar
17.Albert, M, Naeser, MA, Levine, HL, Garvey, AJ. Ventricular size in patients with presenile dementia of the Alzheimer's type. Arch Neurol 1984; 41(12): 1258–1263.CrossRefGoogle ScholarPubMed
18.Arai, H, Kobayashi, K, Ikeda, K, Nagao, Y, Ogihara, R, et al.A computed tomography study of Alzheimer's disease. J Neurol 1983; 229(2): 69–77.Google Scholar
19.Gado, M, Hughes, CP, Danziger, W, Chi, D, Jost, G, et al.Volumetric measurements of the cerebrospinal fluid spaces in demented subjects and controls. Radiology 1982; 144(3): 535–538.CrossRefGoogle ScholarPubMed
20.Brinkman, SD, Sarwar, M, Levin, HS, Morris, HH. Quantitative indexes of computed tomography in dementia and normal aging. Radiology 1981; 138(1): 89–92.CrossRefGoogle ScholarPubMed
21.Jacoby, RJ, Levy, R. Computed tomography in the elderly. 2. Senile dementia: diagnosis and functional impairment. Br J Psychiatry 1980; 136: 256–269.Google ScholarPubMed
22.Drayer, BP, Heyman, A, Wilkinson, W; Barrett, L, Weinberg, T. Earlyonset Alzheimer's disease: an analysis of CT findings. Ann Neurol 1985; 17(4): 407–410.CrossRefGoogle ScholarPubMed
23.Creasey, H, Schwartz, M, Frederickson, H, Haxby, JV, Rapoport, SI. Quantitative computed tomography in dementia of the Alzheimer type. Neurology 1986; 36(12): 1563–1568.CrossRefGoogle ScholarPubMed
24.Luxenberg, JS, Friedland, RP, Rapoport, SI. Quantitative X-ray computed tomography (CT) in dementia of the Alzheimer type (DAT). Can J Neurol Sci 1986; 13(4 Suppl): 570–572.CrossRefGoogle ScholarPubMed
25.Damasio, H, Eslinger, P, Damasio, AR, Rizzo, M, Huang, HK, et al.Quantitative computed tomographic analysis in the diagnosis of dementia. Arch Neurol 1983; 40(12): 715–719.CrossRefGoogle ScholarPubMed
26.Erkinjuntti, T. Differential diagnosis between Alzheimer's disease and vascular dementia: evaluation of common clinical methods. Acta Neurol Scand 1987; 76(6): 433–442.CrossRefGoogle ScholarPubMed
27.Erkinjuntti, T, Ketonen, L, Sulkava, R, Vuorialho, M, Palo, J. CT in the differential diagnosis between Alzheimer's disease and vascular dementia. Acta Neurol Scand 1987; 75(4): 262–270.CrossRefGoogle ScholarPubMed
28.George, AE, de, Leon MJ, Ferris, SH, Kricheff, II. Parenchymal CT correlates of senile dementia (Alzheimer disease): loss of gray-white matter discriminability. Am J Neuroradiol 1981; 2(3): 205–213.Google ScholarPubMed
29.Kemper, T. Neuroanatomical and neuropathological changes in normal aging and dementia. In: Albert, M, ed. Clinical Neurology of Aging. New York: Oxford University Press 1984; 9–52.Google Scholar
30.Tierney, MC, Fisher, RH, Lewis, AJ, Zorzitto, ML, Snow, WG, et al.The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology 1988; 38(3): 359–364.CrossRefGoogle ScholarPubMed
31.Naeser, MA, Gebhardt, C, Levine, HL. Decreased computerized tomography numbers in patients with presenile dementia. Detection in patients with otherwise normal scans. Arch Neurol 1980; 37(7): 401–409.CrossRefGoogle ScholarPubMed
32.Bondareff, W, Baldy, R, Levy, R. Quantitative computed tomography in senile dementia. Arch Gen Psychiatry 1981; 38(12): 1365–1368.CrossRefGoogle ScholarPubMed
33.Colgan, JNaguib, M, Levy, R. Computed tomographic density numbers. A comparative study of patients with senile dementia and normal elderly controls. Br J Psychiatry 1986; 149: 716–719.Google ScholarPubMed
34.Wilson, RS, Fox, JH, Huckman, MS, Bacon, LD, Lobick, JJ. Computed tomography in dementia. Neurology 1982; 32(9): 1054–1057.CrossRefGoogle ScholarPubMed
35.LeMay, M, Stafford, JL, Sandor, T, Albert, M, Haykal, H, et al.Statistical assessment of perceptual CT scan ratings in patients with Alzheimer type dementia. J Comput Assist Tomogr 1986; 10(5): 802–809.CrossRefGoogle ScholarPubMed
36.Wilcock, GK. The temporal lobe in dementia of Alzheimer's type. Gerontology 1983; 29(5): 320–324.CrossRefGoogle ScholarPubMed
37.Wilcock, GK, Esiri, MM. Plaques, tangles and dementia. A quantitative study. J Neurol Sci 1982; 56(2-3): 343–356.CrossRefGoogle ScholarPubMed
38.Ball, MJ. Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia. A quantitative study. Acta Neuropathol (Berl) 1977; 37(2): 111–118.CrossRefGoogle ScholarPubMed
39.Ball, MJ, Lo, P. Granulovacuolar degeneration in the ageing brain and in dementia. J Neuropathol Exp Neurol 1977; 36(3): 474–487.CrossRefGoogle ScholarPubMed
40.Hyman, BT, Van, Horsen GW, Damasio, AR, Barnes, CL. Alzheimer's disease: cell-specific pathology isolates the hip-pocampal formation. Science 1984; 225(4667): 1168–1170.CrossRefGoogle Scholar
41.Hyman, BT, Van, Hoesen GW, Kromer, LJ, Damasio, AR. Perforant pathway changes and the memory impairment of Alzheimer's disease. Ann Neurol 1986; 20(4): 472–481.CrossRefGoogle ScholarPubMed
42.Herzog, AG, Kemper, TL. Amygdaloid changes in aging and dementia. Arch Neurol 1980; 37(10): 625–629.CrossRefGoogle ScholarPubMed
43.Corsellis, J. The limbic areas in Alzheimer's disease and in other conditions associated with dementia. In: Wolstenholme, G, O'Connor, M, eds. Alzhemier's Disease and Related Conditions. London: J&A Churchill 1970; 37–45.Google Scholar
44.LeMay, M, Alvarez, N. The relationship between enlargement of the temporal horns of the lateral ventricles and dementia in aging patients with Down syndrome. Neuroradiology 1990; 32(2): 104–107.CrossRefGoogle ScholarPubMed
45.George, AE, de, Leon MJ, Stylopoulos, LA, Miller, J, Kluger, A, et al.CT diagnostic features of Alzheimer disease: importance of the choroidal/hippocampal fissure complex. Am J Neuroradiol 1990; 11(1): 101–107.Google ScholarPubMed
46.Kido, DK, Caine, ED, LeMay, M, Ekholm, S, Booth, H, et al.Temporal lobe atrophy in patients with Alzheimer disease: a CT study. Am J Neuroradiol 1989; 10(3): 551–555.Google ScholarPubMed
47.LeMay, M.CT changes in dementing diseases: a review. Am J Radiol 1986; 147(5): 963–975.Google ScholarPubMed
48.Sandor, T, Albert, M, Stafford, J, Harpley, S. Use of computerized CT analysis to discriminate between Alzheimer patients and normal control subjects. Am J Neuroradiol 1988; 9(6): 1181–1187.Google ScholarPubMed
49.Folstein, MF, Folstein, SE, McHugh, PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12(3): 189–198.CrossRefGoogle ScholarPubMed
50.Mattis, S. Mental status examination for organic mental syndrome in the elderly patient. In: Bellak, L, Karasu, TB, eds. Geriatric Psychiatry. New York, Grune & Stratton 1976.Google Scholar
51.Kaplan, E, Goodglass, H, Weintraub, S. The Boston Naming Test. Philadelphia, PA: Lea & Febiger 1983.Google Scholar
52.McKhann, G, Drachman, D, Folstein, M, Katzman, R, Price, D, et al.Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34(7): 939–944.CrossRefGoogle ScholarPubMed
53.Neary, D, Snowden, JS, Northen, B, Goulding, P. Dementia of frontal lobe type. J Neurol Neurosurg Psychiatry 1988; 51(3): 353–361.CrossRefGoogle ScholarPubMed
54.Neary, D. Dementia of frontal lobe type. J Am Geriatr Soc 1990; 38(1): 71–72.CrossRefGoogle ScholarPubMed
55.Huberty, CJ. Issues in the use and interpretation of discriminant analysis. Psychol Bull 1984; 95(1): 156–171.CrossRefGoogle Scholar
56.Varga, M, Wortzman, G, Freedman, M. Assessment of cognitive impairment: the role of CT. Can J Neurol Sci 1991; 18(2): 129–131.CrossRefGoogle ScholarPubMed