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Tauopathies: One Disease or Many?

Published online by Cambridge University Press:  02 December 2014

Manon Bouchard  and
Oksana Suchowersky
Manon Bouchard*
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Oksana Suchowersky
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada
*
3350 Hospital DR NW, Calgary, Alberta, T2N 4Z5, Canada
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Abstract

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Tauopathies are a group of disorders that have in common abnormal accumulation of tau protein in the brain. Although the different tauopathies have long been considered to be separate diseases, it is now clear that progressive supranuclear palsy, corticobasal degeneration and some forms of tau-positive frontotemporal lobar degeneration share clinical, pathological and genetic features. The important overlap between these disorders suggest they may represent different phenotypes of a single disease process, the clinical result depending on the topography of pathological lesions as well as other unknown factors.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 4 , July 2011 , pp. 547 - 556
Copyright
Copyright © The Canadian Journal of Neurological 2011

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