It was with considerable hesitation that I finally accepted the kind invitation of Vernon Brooks and the Organizing Committee of this Symposium to say a few words at the end giving some of my impressions of the presentations and discussion and reflections on the remarkable advances in our knowledge of motor systems that has occurred during recent years. I have been asked also if I would try to place some of these findings from experimental laboratories in the context of clinical experience with diseases and disorders of motor control. I would like to draw particular attention to the importance of state dependent reactions in which patterns of behavior are set up, even including spinal reflexes, by present programs depending on the general or directional reactive state of the organism.