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Status of Current Clinical Trials in Diabetic Polyneuropathy

Published online by Cambridge University Press:  02 December 2014

Vera Bril
Vera Bril*
Affiliation:
Toronto General Hospital, UHN, University of Toronto, Toronto, Ontario, Canada
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Abstract

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Peripheral polyneuropathy is the most frequent complication of diabetic mellitus. In spite of many clinical trials of different specific interventions for diabetic polyneuropathy, intensive glycemic control remains the only effective specific therapy currently available for this troublesome complication. This systematic overview reports the status of current clinical trials in diabetic polyneuropathy with an emphasis on those interventions directed towards specific pathophysiological derangements. A discussion of clinical trials of agents directed towards relieving painful symptoms of diabetic polyneuropathy concludes this overview.

Résumé

RÉSUMÉ

La polyneuropathie périphérique est la complication la plus fréquente du diabète. En dépit de nombreux essais cliniques, le contrôle glycémique intensif demeure le seul traitement spécifique efficace disponible actuellement pour traiter cette complication importante. Cette revue systématique fait le point sur les essais cliniques en cours ciblant des perturbations physiopathologiques spécifiques. Une discussion des essais cliniques d’agents utilisés pour soulager la douleur due à la polyneuropathie diabétique est présentée en guise de conclusion À cette revue.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 28 , Issue 3 , August 2001 , pp. 191 - 198
Copyright
Copyright © The Canadian Journal of Neurological 2001

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