Hostname: page-component-77c89778f8-m8s7h Total loading time: 0 Render date: 2024-07-24T00:58:44.700Z Has data issue: false hasContentIssue false
  • English
  • Français

Platelet taurine content in Friedreich's disease

Published online by Cambridge University Press:  18 September 2015

F. Rodrigue ,
F. Bélanger ,
N.M. van Gelder  and
A. Barbeau
F. Rodrigue
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
F. Bélanger
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
N.M. van Gelder
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
A. Barbeau*
Affiliation:
Clinical Research Institute of Montreal, and the Université de Montréal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We have studied the concentrations of taurine and of 6 other amino acids in platelets from 12 patients with Friedreich's disease and 12 age sex-matched normal control subjects. No significant differences could be demonstrated between the two groups. The glycine/serine ratio was lower in all the patients but this change did not reach statistical significance. From these and other data, we conclude that the taurine retention deficit observed previously in Friedreich's disease cannot be the primary causal defect.

Type
C—Biochemistry
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S4 , November 1984 , pp. 607 - 609
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

References

Azari, J, Brumbauch, P, Barbeau, A, Huxtable, R (1980) Taurine decreases lesion severity in the heart of cardiomyopathic hamsters. Can J Neurol Sci 7: 435–440.CrossRefGoogle ScholarPubMed
Barbeau, A (1982) Friedreich’s disease 1982: Etiologic hypothese — A personal analysis. Can J Neurol Sci 9: 243–263.CrossRefGoogle ScholarPubMed
Barbeau, A, Patenaude, F, Nadon, G, Charbonneau, M, Cloutier, T (1982) A possible genetic pattern of taurine urinary excretion in Friedreich’s ataxia. Can J Neurol Sci 9: 209–215.CrossRefGoogle ScholarPubMed
Filla, A, Butterworth, RF, Barbeau, A (1979) Pilot studies on membranes and some transport mechanism in Friedreich’s ataxia. Can J Neurol Sci 6: 285–289.CrossRefGoogle ScholarPubMed
Filla, A, Butterworth, RF, Geoffroy, G, Lemieux, B, Barbeau, A (1978) Platelet taurine uptake in spino-cerebellardegeneration. Can J Neurol Sci 5: 119–123.CrossRefGoogle Scholar
Fredo, J, Koj, A, Zgliczynski, JM (1959) Taurine in human blood platelets. Nature 183: 685–686.CrossRefGoogle Scholar
Geoffroy, G, Barbeau, A, Breton, G, Lemieux, B, Aubé, M, Léger, C, Bouchard, JP (1976). Clinical description and roentgenologic evaluation of patients with Friedreich’s ataxia. Can J Neurol Sci 3: 279–286.CrossRefGoogle ScholarPubMed
Goodman, HD, Connolly, BM, McLean, W, Resnick, M (1980) Taurine transport in epilepsy. Clin Chem 26: 414–419.CrossRefGoogle ScholarPubMed
Huang, YS, Marcel, YL, Vezina, C, Barbeau, A, Davignon, J (1980) Lecithin: cholesterol acyltransferase activity and fatty acid composition of erythrocyte phospholipids in Friedreich’s ataxia. Can J Neurol Sci 7: 429–434.CrossRefGoogle ScholarPubMed
Huxtable, R, Azari, J, Reisine, T, Johnson, P, Yamamura, H and Barbeau, A (1979) Regional distribution of amino acids in Friedreich’s ataxia brains. Can J Neurol Sci 6: 255–258.CrossRefGoogle ScholarPubMed
Koyanagi, T, Obori, H (1965) Effect of pantothenic acid and vitamin B6 on the excretion of taurine in the urine of rats. Tohoku J Exp Med 86:394–396.CrossRefGoogle ScholarPubMed
Lemieux, B, Barbeau, A, Beroniade, V, Shapcott, D, Breton, G, Geoffroy, G, Melancon, S (1976) Amino acid metabolism in Friedreich’s ataxia. Can J Neurol Sci 3: 373–378.CrossRefGoogle ScholarPubMed
Lemieux, B, Giguere, R, Barbeau, A, Melancon, S, Shapcott, D (1978) Taurine in cerebrospinal fluid in Friedreich’s ataxia. Can J Neurol Sci 5: 125–129.CrossRefGoogle ScholarPubMed
Lowry, OH, Rosenbrough, NJ, Farr, AL, Randall, RJ (1951) Protein measurement with the folin phenol reagent. Meth Enzymol 3:447–454.Google Scholar
Melançon, SB, Grignon, B, Ledru, E, Geoffroy, G, Potier, M, Dallaire, L, Vanasse, M (1980) The Beta-amino acid transport system in Friedreich’s ataxia. Can J Neurol Sci 7: 441–446.CrossRefGoogle ScholarPubMed
Melançon, SB, Grignon, B, Potier, M, Dallaire, L (1979) Taurine and Beta-alanine uptake in cultured human skin fibroblasts from patients with Friedreich’s ataxia. Can J Neurol Sci 6: 251–253.CrossRefGoogle ScholarPubMed
Paasonen, MK, Penttila, O, Hiniberg, JJ, Solatunturi, E (1980) Platelet taurine in patients with arterial hypertension, myocardial failure or infarction. Acta Med Scand (supp). 642: 79–84.CrossRefGoogle ScholarPubMed
van Gelder, NM (1983) Principles of Compartmentation. In: Lajtha, A (ed.). Handbook of Neurochemistry, Plenum Publishing Corp., vol. 2 (2nd edition), pp 183–206.Google Scholar
Yorek, MA, Strom, DK, Spector, AA (1984) Effect of membrane polyunsaturate on carrier-mediated transport in cultured retinoblastoma cells: alterations in taurine uptake. J Neurochemistry 42: 254–261.CrossRefGoogle ScholarPubMed