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Pain Free Efficacy of Sumatriptan in the Early Treatment of Migraine

Published online by Cambridge University Press:  02 December 2014

Susan E. Jelinski ,
Werner J. Becker ,
Suzanne N. Christie ,
Faiz F. Ahmad ,
William Pryse-Phillips  and
Scott D. Simpson
Susan E. Jelinski
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
Werner J. Becker*
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
Suzanne N. Christie
Affiliation:
Department of Radiology, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke University, Sherbrooke, QC, Canada
Faiz F. Ahmad
Affiliation:
GlaxoSmithKline, Mississauga, ON, Canada
William Pryse-Phillips
Affiliation:
GlaxoSmithKline, Mississauga, ON, Canada Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada
Scott D. Simpson
Affiliation:
GlaxoSmithKline, Mississauga, ON, Canada
*
Department of Clinical Neurosciences, Foothills Medical Centre, 12th Floor, Neurology, 1403-29th Street NW, Calgary, Alberta, T2N 2T9, Canada
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Abstract:

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Background:

There is evidence that headache response rates may be higher if triptans are used early when a migraine attack is still mild, as compared to when it is treated after pain has reached moderate or severe intensity.

Methods:

In this randomized, double blind, placebo controlled, parallel group clinical trial, 361 patients took either placebo, sumatriptan 50 mg, or sumatriptan 100 mg in a single attack study. The primary outcome measure was pain-free status at two hours.

Results:

In the intention to treat group, two hour pain free rates were 16%, 40%, and 50% in the placebo group, sumatriptan 50 mg group, and the sumatriptan 100 mg group respectively (p<0.001, active treatment groups vs. placebo).

Conclusions:

Both sumatriptan 50 mg and 100 mg were significantly superior to placebo for the pain-free end point at two hours. The pain-free response rates in this trial where sumatriptan was taken while the headache was still mild were generally higher than in older clinical trials where headache was treated after reaching a moderate or severe intensity.

Résumé

RÉSUMÉContexte:

Le taux de réponse serait plus élevé si les triptans sont utilisés tôt au cours d’une crise de migraine alors que les symptômes sont légers plutôt que quand la douleur est devenue modérée ou sévère.

Méthodes:

Il s’agit d’une étude de pharmacologie clinique randomisée, à double insu, avec placebo et groupes parallèles. 361 patients ont pris soit le placebo, le sumatriptan 50 mg ou le sumatriptan 100 mg au cours d’une seule crise migraineuse. Le critère d’évaluation primaire était l’absence de douleur 2 heures après la prise du médicament.

Résultats:

À l’analyse selon l’intention de traitement, le taux de patients sans douleur était de 16%, 40% et 50% pour le groupe placebo, le groupe sumatriptan 50 mg et le groupe sumatriptan 100 mg respectivement (groupes traitement actif versus placebo, p ˃ 0,001).

Conclusions:

Le sumatriptan 50 mg et 100 mg étaient significativement supérieurs au placebo quant au critère d’évaluation primaire, soit l’absence de douleur 2 heures après la prise du médicament. Le taux de réponse, soit l’absence de douleur, dans cette étude où le sumatriptan était pris alors que la céphalée était encore légère, était généralement plus élevé que dans d’autres essais cliniques où la céphalée était traitée alors qu’elle était modérée ou sévère.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 33 , Issue 1 , February 2006 , pp. 73 - 79
Copyright
Copyright © The Canadian Journal of Neurological 2006

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