Background: Earlier studies suggest that age and stroke severity are the main determinants in stroke patient disposition after rehabilitation. We examined these and other variables to determine those that correlated with returning home vs. long-term care (LTC). Methods: Chart review of ischemic stroke patients with initial alpha-FIM scores between 40 and 80 admitted to our Rehabilitation Unit from January 1, 2005 to December 31, 2014. Univariate and multivariate analyses were performed. Results: There were 162 suitable patients. 130 went home and 32 went to LTC. The multivariable analysis showed the following variables favored LTC disposition: age (1.2x increased risk with increased age, P<0.01), residence (17.5x increased risk if not starting at home, P<0.01), right vs. left hemisphere (5.4x greater risk with right hemisphere, p=0.01), bowel continence (10.6x greater risk if not continent, p<0.01), and caregiver (0.05x decreased risk if a caregiver is present, p<0.01). No differences were found for sex, diabetes mellitus, atrial fibrillation, previous stroke, congestive heart failure, COPD, obesity, hemianopsia or financial status. Conclusions: Numerous variables probably affect patient disposition after rehabilitation for acute ischemic stroke.