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Origin of Friedreich's Disease in Quebec

Published online by Cambridge University Press:  18 September 2015

A. Barbeau ,
M. Sadibelouiz ,
M. Roy ,
B. Lemieux ,
J.P. Bouchard  and
G. Geoffroy
A. Barbeau*
Affiliation:
Clinical Research Institute of Montreal
M. Sadibelouiz
Affiliation:
Clinical Research Institute of Montreal University of Alger, Algeria
M. Roy
Affiliation:
Clinical Research Institute of Montreal
B. Lemieux
Affiliation:
Centre Hospitalier Universitaire de Sherbrooke, Algeria
J.P. Bouchard
Affiliation:
Hôpital de I'Enfant-Jésus, Québec
G. Geoffroy
Affiliation:
Hôpital Sainte-Justine, Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada, H2W 1R7
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Abstract

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We have been able to trace 40 cases of classical Friedreich's disease from 14 previously unrelated French Canadian kindreds to one common ancestral couple arriving in New France in 1634: Jean Guyon and Mathurine Robin.

One member of this couple presumably introduced one gene for Friedreich's disease into the French Canadian population. This gene has now been traced over 12 generations to both parents of the present cases. We plan to use this knowledge to study the spectrum of clinical manifestations of this gene and to carry out gene chromosomal localization studies, using the techniques of linkage and of molecular biology. Such studies in rare autosomal recessive disorders have previously been judged to be almost impossible.

Type
A—Clinical Studies
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S4 , November 1984 , pp. 506 - 509
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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