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Neuronal Growth Factors from Tumours of Von Recklinghausen Neurofibromatosis

Published online by Cambridge University Press:  18 September 2015

Richard J. Riopelle  and
Vincent M. Riccardi
Richard J. Riopelle*
Affiliation:
Department of Medicine (Neurology), Queen's University, Kingston, Ontario, Canada, and The Department of Medicine and Neurofibromatosis Program, Baylor College of Medicine, Houston, Texas
Vincent M. Riccardi
Affiliation:
Department of Medicine (Neurology), Queen's University, Kingston, Ontario, Canada, and The Department of Medicine and Neurofibromatosis Program, Baylor College of Medicine, Houston, Texas
*
La Salle Building, Queen's University, Kingston, Ontario, Canada K7L 3N6
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Abstract:

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Explants of 21 neurofibromas from 16 patients with Von Recklinghausen neurofibromatosis (NF-I) plus tumour tissue from 5 comparison patients and normal tissue from one of the NF-I patients were assayed for neuronal growth factor(s) using dissociated embryonic sensory neurons from chick embryo. Twenty-one of 21 neurofibroma explants released detectable quantities of neuronal growth factors, but only 2 of 8 non-neurofibroma tissue explants released activity.

While antiserum to mouse nerve growth factor (NGF) fractionally inhibited neurite outgrowth induced by some of the neurofibromas, overall differences between assays containing antibody and controls reached statistical significance in 3 cases; in one case, explants of a separate tumourfrom the same patient had no detectable NGF-like activity.

These data support the hypothesis that local release of neuronal growth factors in neurofibromas are responsible for neurites observed within these tumours. Further evidence that endoneurial tissue of peripheral nerve is a rich source of heterogeneous neuronal growth facts has been provided by these studies.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue 2 , May 1987 , pp. 141 - 144
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

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