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Narcolepsy Secondary to Fourth Ventricular Subependymoma

Published online by Cambridge University Press:  18 September 2015

T.K.F. Ma ,
L.C. Ang ,
M. Mamelak ,
S.J. Kish ,
B. Young  and
A.J. Lewis
T.K.F. Ma
Affiliation:
Division of Pathology, Sunnybrook Health Science Centre, University of Toronto, Toronto
L.C. Ang*
Affiliation:
Division of Pathology, Sunnybrook Health Science Centre, University of Toronto, Toronto
M. Mamelak
Affiliation:
Department of Psychiatry, Boycrest Centre, University of Toronto, Toronto
S.J. Kish
Affiliation:
Clarke Institute of Psychiatry, University of Toronto, Toronto
B. Young
Affiliation:
Division of Pathology, Sunnybrook Health Science Centre, University of Toronto, Toronto
A.J. Lewis
Affiliation:
Division of Pathology, Sunnybrook Health Science Centre, University of Toronto, Toronto
*
Division of Pathology (Neuropathology) E419. Sunnybrook Health Science Centre, University of Toronto. 2075 Bayview Avenue, North York. Ontario. Canada M4N 3M5
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Abstract:

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Background:

Secondary (symptomatic) narcolepsy is rare. We report a subependymoma of the fourth ventricle associated with narcolepsy. The patient was a 50-year-old woman with a long history of narcolepsy who died of colonic carcinoma with no cerebral metastasis. She was positive for HLA-DR2. At autopsy there was a tumour dorsal to the fourth ventricle which involved the midbrain tectum and rostral pons. Histologic examination of the tumour confirmed it to be a subependymoma.

Methods:

Review of the previous cases of secondary narcolepsy was made with particular reference to the anatomical location of the lesions.

Results:

Most of the lesions were found around the third ventricle and rostral brainstem.

Conclusions:

Knowing the anatomical localization of the pathological changes in secondary narcolepsy could be important in improving our understanding of its pathogenesis.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 23 , Issue 1 , February 1996 , pp. 59 - 62
Copyright
Copyright © Canadian Neurological Sciences Federation 1996

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