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Lecithin: Cholesterol Acyltransferase Activity and Fatty Acid Composition of Erythrocyte Phospholipids in Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

Y.S. Huang ,
Y.L. Marcel ,
C. Vezina ,
A. Barbeau  and
J. Davignon
Y.S. Huang
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research, the Laboratory of Lipid Research and the Department of Neurobiology, Clinical Research Institute of Montreal
Y.L. Marcel
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research, the Laboratory of Lipid Research and the Department of Neurobiology, Clinical Research Institute of Montreal
C. Vezina
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research, the Laboratory of Lipid Research and the Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau*
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research, the Laboratory of Lipid Research and the Department of Neurobiology, Clinical Research Institute of Montreal
J. Davignon
Affiliation:
Department of Lipid Metabolism and Atherosclerosis Research, the Laboratory of Lipid Research and the Department of Neurobiology, Clinical Research Institute of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal,Quebec H2W 1R7
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In a study of the fatty acid composition of erythrocyte membrane phospholipids in Friedreich's ataxia, a lower percentage of linoleic acid in phosphatidylcholine was demonstrated. An enzyme involving the exchange of lipids between plasma and erythrocyte membrane, lecithin: cholesteryl acyltransferase (LCAT) was also studied. It was found that the LCA Tactivity had a trend towards low values. However, crossing-over studies indicated that when the LCAT enzyme of patients was exposed to its own substrate it gave low activity values but that the result reverted to normal when control substrate was used

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 429 - 434
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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