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Jakob-Creutzfeldt Disease Associated with Wernicke Encephalopathy

Published online by Cambridge University Press:  18 September 2015

S. Gaytan-Garcia ,
J.J. Gilbert ,
J.H.N. Deck  and
J.C.E. Kaufmann
S. Gaytan-Garcia
Affiliation:
University Hospital, Victoria Hospital, London
J.J. Gilbert
Affiliation:
University Hospital, Victoria Hospital, London
J.H.N. Deck
Affiliation:
Toronto General Hospital, Toronto
J.C.E. Kaufmann*
Affiliation:
University Hospital, Victoria Hospital, London
*
University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5
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Abstract:

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Wernicke disease (WD) is a complication of alcoholism and malnutrition and usually presents acutely and is characterized by disturbances of consciousness, paralysis of the external ocular muscles, and ataxia. The disease results from deficiency of vitamin B 1, or thiamine, an essential coenzyme in intermediate carbohydrate metabolism. On the other hand, Jakob-Creutzfeldt disease (J-C) results from infection with an unconventional agent with a long incubation period and is characterized by a rapidly progressive dementia and histologically by a spongiform encephalopathy associated with neuronal destruction and pronounced astrogliosis. Combination of both diseases has not been reported in the literature previously and their relationship is uncertain. We present 3 cases with this interesting association and consider their relationship.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 2 , May 1988 , pp. 156 - 160
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

References

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