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HL-A Frequencies in Patients with Multiple Sclerosis*

Published online by Cambridge University Press:  18 September 2015

D.W. Paty ,
H. Mervart ,
B. Campling ,
C.G. Rand  and
C.R. Stiller
D.W. Paty*
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
H. Mervart
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
B. Campling
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
C.G. Rand
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
C.R. Stiller
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
*
University Hospital, 339 Windermere Road, London, Ontario N6G 2K3, Canada
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The histocompatibility antigens (HL-A) have been determined in 100 multiple sclerosis (M.S.) patients and 143 randomly selected controls. In the M.S. group there was a statistically significant increase in the frequency of HL-A 7 and W 18 with an insignificant increase in HL-A 3. The variance from normal HL-A patterns in the M.S. population may play some role in establishing the substrate for this disease. Studies in experimental animals have shown that susceptibility to autoimmune disease and to virus infection is linked to the major histocompatibility locus. This has interesting implications for both the “slow virus” and the “autoimmune” theories of the etiology of multiple sclerosis.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 1 , Issue 4 , November 1974 , pp. 211 - 213
Copyright
Copyright © Canadian Neurological Sciences Federation 1974

Footnotes

*

This material was presented in part at the Royal College of Physicians and Surgeons (Canada) Meeting in Montreal, January 25, 1974.

References

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