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HL-A Frequencies in Patients with Multiple Sclerosis*

Published online by Cambridge University Press:  18 September 2015

D.W. Paty*
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
H. Mervart
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
B. Campling
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
C.G. Rand
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
C.R. Stiller
Affiliation:
Departments of Clinical Neurological Sciences, Epidemiology and Preventive Medicine, and Medicine, The University of Western Ontario, London, Canada
*
University Hospital, 339 Windermere Road, London, Ontario N6G 2K3, Canada
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The histocompatibility antigens (HL-A) have been determined in 100 multiple sclerosis (M.S.) patients and 143 randomly selected controls. In the M.S. group there was a statistically significant increase in the frequency of HL-A 7 and W 18 with an insignificant increase in HL-A 3. The variance from normal HL-A patterns in the M.S. population may play some role in establishing the substrate for this disease. Studies in experimental animals have shown that susceptibility to autoimmune disease and to virus infection is linked to the major histocompatibility locus. This has interesting implications for both the “slow virus” and the “autoimmune” theories of the etiology of multiple sclerosis.

Type
Research Article
Copyright
Copyright © Canadian Neurological Sciences Federation 1974

Footnotes

*

This material was presented in part at the Royal College of Physicians and Surgeons (Canada) Meeting in Montreal, January 25, 1974.

References

REFERENCES

Arnason, B.G.W., Fuller, T.C, Lehrich, J.R., and Wray, S.H. (1974). Histocompatibility types and measles antibodies in multiple sclerosis and optic neuritis. Journal of the Neurological Sciences 22, 419428.CrossRefGoogle ScholarPubMed
Bertrams, J., and Kuwert, E. (1972). HL-A antigen frequencies in multiple sclerosis. Significant increase of HL-A 3, HL-A 10 and W5, and decrease of HL-A 12. Eurp Neurol. 7, 7478.CrossRefGoogle Scholar
Gasser, D.L., Newlin, C.M., Palm, J., Gonatas, N.K. (1973). Genetic control of susceptibility to experimental allergic encephalomyelitis in rats. Science 181, 872873.CrossRefGoogle ScholarPubMed
Jersild, C., Svejgaard, A., Fog, T., and Ammitzboll, T. (1973). HL-A antigens and diseases. I. multiple sclerosis. Tissue Antigens 3, 243250.CrossRefGoogle ScholarPubMed
Jersild, C., Ammitzboll, T., Clausen, J., and Fog, T. (1973a). Association between HL-A antigens and measles antibody in multiple sclerosis. The Lancet 1, 151152.CrossRefGoogle ScholarPubMed
Jersild, C., Hansen, G.S., Svejgaard, A., Fog, T., Thomsen, M., and Dupont, B. (1973b). Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. The Lancet 4, 12211226.CrossRefGoogle Scholar
Lilly, F. (1966). The inheritance of susceptibility to the gross leukemia virus in mice. Genetics 53, 529539.CrossRefGoogle Scholar
Mackay, R.P., and Myrian-Thopoulos, N.C. (1966). Multiplesclerosis in twins and their relatives, Final Report. Archives of Neurology (Chicago) 15, 449462.CrossRefGoogle Scholar
McDevitt, H.O., and Benacerraf, B. (1969). Genetic control of specific immune responses. Advances in Immunology, Vol. 2, 3274.Google Scholar
McDevitt, H.O., and Bodmer, W.F. (1972). Histocompatibility antigens, immune responsiveness and susceptibility to disease. The American Journal of Medicine 52, 18.CrossRefGoogle Scholar
Mittal, K.K., Mickey, M.R., Singal, D.P., and Terasaki, P.I. (1968). Serotyping for homotransplantation. XVIII. Refinement of microdroplet Lymphocytotoxicity test. Transplantation 6, 913920.CrossRefGoogle Scholar
Morris, P.J., and Pietsch, M.C. (1973). A possible association between paralytic poliomyelitis and multiple sclerosis. The Lancet 3, 847848.CrossRefGoogle Scholar
Naito, S., Namerow, N., Mickey, M.R., and Terasaki, P.I. (1972). Multiple sclerosis: association with HL-A 3. Tissue Antigens 2, 14.CrossRefGoogle Scholar
Schumacher, G.A., Beebe, G., Kibler, R.F., Kurland, L.T., Kurtzke, J.F., Mcdowell, F., Nagler, B., Sibley, W.A., Tour-Tellotte, W.W., and Willmon, T.L. (1965). Problems of experimental trials of therapy in multiple sclerosis: Report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Annals New York Academy of Sciences 122, 552568.CrossRefGoogle Scholar
Vladutiu, A.O., and Rose, N.R. (1971). Autoimmune murine thyroiditis relation to histocompatibility (H-2) type. Science 174, 11371139.CrossRefGoogle ScholarPubMed
Williams, R.M., and Moore, M.J. (1973). Linkage of susceptibility to experimental allergic encephalomyelitis to the major histocompatibility locus in the rat. The Journal of Experimental Medicine 138, 775783.CrossRefGoogle Scholar