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Function of the Basal Ganglia as Revealed by Cognitive and Motor Disorders in Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

C.D. Marsden
C.D. Marsden*
Affiliation:
University Department of Neurology, Institute of Psychiatry and King’s College Hospital, London
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Abstract

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Early Parkinson’s disease is taken to be the best human model of disordered basal ganglia function. An experimental study in Parkinsonians with swings in motor response to drug treatment suggests that general cognition is not controlled by dopamine mediated striatal activity. The variety of motor disorders in Parkinson’s disease cannot be explained by simple concepts. Although Parkinsonians cannot execute fast ballistic movements, an experimental study shows that they can adopt a predictive motor control strategy. It is argued that simple motor programs are not grossly disturbed in Parkinson’s disease. It is concluded that Parkinsonians cannot automatically execute learned motor plans.

Type
2. Physiology of the Basal Ganglia and Pathophysiology of Parkinson’s Disease
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S1: Current Concepts and Controversies in Parkinson’s Disease , February 1984 , pp. 129 - 135
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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