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Frontal Lobe and Kindling in the Rat

Published online by Cambridge University Press:  18 September 2015

Michael E. Corcoran ,
Harald Urstad ,
James A. McCaughran JR.  and
Juhn A. Wada
Michael E. Corcoran*
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
Harald Urstad
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
James A. McCaughran JR.
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
Juhn A. Wada
Affiliation:
Division of Neurological Sciences, University of British Columbia, Vancouver, British Columbia
*
Division of Neurological Sciences, University of British Columbia, 2075 Wesbrook Place, Vancouver V6T 1W5 Canada
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To test the hypothesis that the cortex participates in amygdaloid kindling in rats, bilateral aspiration lesions were made in various cortical areas in rats prior to kindling. Lesions in orbital cortex (on the dorsal lip of the rhinal sulcus) or prefrontal cortex (area 10) significantly retarded the rate of amygdaloid kindling; lesions in motor cortex, anterior cingulate cortex, or visual cortex were without effect. Detailed analysis indicated that the orbital lesioned and frontal-lesioned rats kindled relatively normally up to the second-last stage of amygdaloid kindling, in which stage they perseverated significantly longer than the controls and the other lesioned rats. These results suggest that areas of the frontal lobe participate in the elaboration and generalization of amygdaloid seizures in rats. Although retarded in rate, kindling nonetheless occurred in the lesioned rats, indicating that these cortical areas are not essential for the development of amygdaloid seizures.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 2 , Issue 4 , November 1975 , pp. 501 - 508
Copyright
Copyright © Canadian Neurological Sciences Federation 1975

References

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