Hostname: page-component-77c89778f8-vpsfw Total loading time: 0 Render date: 2024-07-17T16:10:52.447Z Has data issue: false hasContentIssue false
  • English
  • Français

Febrile Seizures in Epileptic Chicks: The effects of Phenobarbital, Phenytoin and Valproate

Published online by Cambridge University Press:  18 September 2015

D.D. Johnson ,
K.D.A. Crawford  and
R.D. Crawford
D.D. Johnson*
Affiliation:
Department of Pharmacology, College of Medicine and the Department of Animal and Poultry Science, College of Agriculture, University of Saskatchewan, Saskatoon
K.D.A. Crawford
Affiliation:
Department of Pharmacology, College of Medicine and the Department of Animal and Poultry Science, College of Agriculture, University of Saskatchewan, Saskatoon
R.D. Crawford
Affiliation:
Department of Pharmacology, College of Medicine and the Department of Animal and Poultry Science, College of Agriculture, University of Saskatchewan, Saskatoon
*
Dept. of Pharmacology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 0W0.
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Epileptic seizures can be evoked in chicks homozygous for the epileptic seizure gene (epi, epi) by elevating their body temperature using microwave diathermy. These seizures precede and differ in motor seizure pattern from a second clonic-tonic seizure produced by hyperthermia in both epileptic and carrier (heterozygote, Epi, epi) chicks. Hyperthermia did not evoke seizures in adult epileptic chickens. Phenobarbital delayed the onset of epileptiform seizures whereas phenytoin and valproate had no effect. These data suggest that epileptic chicks may provide a suitable model for studies on febrile convulsions.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 2 , May 1983 , pp. 96 - 99
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

References

Cavazzuti, G.B. (1975). Prevention of febrile convulsions with dipropylacetate (Depakine). Epilepsia 16:647–648.Google ScholarPubMed
Crawford, R.D. (1970). Epileptiform seizures in domestic fowl. J. Hered. 61: 185–188.CrossRefGoogle ScholarPubMed
Crichlow, E.C. and Crawford, R.D. (1974). Epileptiform seizures in domestic fowl II. Intermittent light stimulation and the electroencephalogram. Can. J. Physiol. Pharmacol. 52: 424–429.CrossRefGoogle ScholarPubMed
Davis, H.L., Johnson, D.D. and Crawford, R.D. (1978). Epileptiform seizures in domestic fowl VII. Plasma phenytoin concentrations and anticonvulsant activity. Can. J. Physiol. Pharmacol. 56: 310–315.CrossRefGoogle ScholarPubMed
Faero, E., Kastrup, K.W., Lykkegaard, N.E., Melchior, J.C. and Thorn, I. (1972). Successful prophylaxis of febrile convulsions with phenobarbital. Epilepsia 13: 279–285.CrossRefGoogle ScholarPubMed
Johnson, D.D., Davis, H.L., Bailey, D.G. and Crawford, R.D. (1977). Epileptiform seizures in domestic fowl VI. Plasma phenobarbital concentrations and anticonvulsant activity. Can. J. Physiol. Pharmacol. 55: 848–854.CrossRefGoogle ScholarPubMed
Johnson, D.D., Davis, H.L. and Crawford, R.D. (1979). Pharmacological and biochemical studies in epileptic fowl. Fed. Proc. 38: 2417–2433.Google ScholarPubMed
Julien, R.M. and Fowler, G.W. (1977). A comparative study of the efficacy of newer antiepileptic drugs on experimentally-induced febrile convulsions. Neuropharmacology 16: 719–724.CrossRefGoogle ScholarPubMed
Kasting, N.W., Veale, W.L., Cooper, K.E., and Lederlis, K. (1981). Vasopressin may mediate febrile convulsions. Brain Research 213, 327–333.CrossRefGoogle ScholarPubMed
Lennox-Buchthal, M. (1971). Febrile and nocturnal convulsions in monozygotic twins. Epilepsia 12: 147–156.Google ScholarPubMed
Melchior, J.C., Buchthal, F. and Lennox-Buchthal, M. (1971). The ineffectiveness of diphenylhydantoin in preventing febrile convulsions in the age of greatest risk, under three years. Epilepsia 12: 55–62.CrossRefGoogle ScholarPubMed
Millichap, J.G. (1959). Studies in febrile seizures 1. Height of body temperature as a measure of the febrile-seizure threshold. Pediatrics 23: 76–85.CrossRefGoogle Scholar
Millichap, J.G. (1965). Anticonvulsant drugs. In. Physiological Pharmacology: A comprehensive treatise. (Root, W.S. and Hofman, F.G. eds.) vol. II. Part B pp. 97–174, Academic Press, New York.Google Scholar
Ounsted, C. (1971). Some aspects of seizure disorders. In Gairdner, D., Hull, D. (editors), Recent advances in paediatrics. London. J.A. Churchill.Google Scholar
Ross, E.M. (1973). Convulsive disorders in British children. Proc. R. Soc. med. 66 703–704.Google ScholarPubMed
Schmidt, R.P., Ward, A.A.J, and Wolfe, W.J. (1956). Failure of hyperthermia to activate experimental epileptogenic foci in monkey. J. Pediat. 48: 180–186.CrossRefGoogle ScholarPubMed
Tsuboi, T. (1977). Genetic aspects of febrile convulsions. Hum. Genet. 38: 169–173.CrossRefGoogle ScholarPubMed
Van den Berg, B.J. and Yerushalmy, J. (1959). Studies on convulsive disorders in young children 1. Incidence of febrile and non-febrile convulsions by age and other factors. Pediat. Res. 3: 298–304.CrossRefGoogle Scholar