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Disconnections in Infantile-Onset Saccade Initiation Delay: A Hypothesis

Published online by Cambridge University Press:  23 September 2016

Michael S. Salman  and
Kristin M. Ikeda
Michael S. Salman*
Affiliation:
Section of Pediatric Neurology, Children's Hospital, University of Manitoba, Winnipeg, Manitoba
Kristin M. Ikeda
Affiliation:
Faculty of Health Sciences, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
*
Section of Pediatric Neurology, Children's Hospital, AE 308, 820 Sherbrook Street, Winnipeg, Manitoba, R3A 1R9, Canada
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Abstract

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Infantile-onset saccade initiation delay (ISID), commonly known as congenital ocular motor apraxia, is characterized by difficulty in triggering horizontal volitional saccades. It typically presents with head thrusts in infancy and is often associated with developmental delay. Patients with ISID are reported to have abnormalities in various brain regions including the corpus callosum, brainstem, and cerebellum. We propose that ISID is caused by the disruption or disconnection of axons linking analogous brain regions involved in processing saccades across the two sides of the brain or bilateral damage to these regions.

Résumé

Résumé

Le délai dans le déclenchement des saccades qui commence dans l'enfance (DDSE), connu sous le nom d'apraxie oculomotrice congénitale, est caractérisé par une difficulté à déclencher des saccades volontaires horizontales. On l'observe de façon typique lors de mouvements brusques de la tête chez les nourrissons et il est souvent associé à un retard de développement. Des anomalies dans différentes régions du cerveau ont été rapportées chez les patients qui présentent un DDSE, dont le corps calleux, le tronc cérébral et le cervelet. Nous émettons l'hypothèse que le DDSE est dû à une perturbation ou à une déconnexion des axones qui relient des régions analogues du cerveau qui sont impliquées dans le traitement des saccades entre les deux hémisphères ou à un dommage bilatéral dans ces régions.

Type
Medical Hypothesis
Information
Canadian Journal of Neurological Sciences , Volume 37 , Issue 6 , November 2010 , pp. 779 - 782
Copyright
Copyright © The Canadian Journal of Neurological 2010

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