Hostname: page-component-76fb5796d-45l2p Total loading time: 0 Render date: 2024-04-25T21:22:20.869Z Has data issue: false hasContentIssue false
  • English
  • Français

Depression in Parkinson's Disease

Published online by Cambridge University Press:  02 December 2014

Barbara Jasinska-Myga ,
John D. Putzke ,
Christian Wider ,
Zbigniew K. Wszolek  and
Ryan J. Uitti
Barbara Jasinska-Myga
Affiliation:
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA Department of Neurology, Aging, Degenerative and Cerebrovascular Disorders, Medical University of Silesia, Katowice, Poland
John D. Putzke
Affiliation:
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
Christian Wider
Affiliation:
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
Zbigniew K. Wszolek
Affiliation:
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
Ryan J. Uitti*
Affiliation:
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA
*
Department of Neurology, Cannaday Building 2E, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida, 32224, USA.
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

To examine predictive factors associated with onset of depression among individuals diagnosed with Parkinson's disease (PD).

Background:

Depression may precede or follow symptomatic parkinsonism in PD. It is frequently treatable but often overlooked.

Methods:

The clinical series comprised 685 individuals who were diagnosed with PD and followed by one neurologist (RJU) from 1994 to 2007. The primary outcome was time to depression following the onset of PD. Diagnosis of depression was based on clinical assessment of depressive symptoms from patients (and spouse/family/caregiver) and antidepressant usage. A number of demographic, historical and clinical predictive factors were examined, including gender, age at symptomatic onset, disease duration, onset characteristics, clinical ratings, antiparkinsonian medications, cognitive status, depression history, and familial history of PD and other neurodegenerative disorders.

Results:

Seventy-two percent of patients developed depression within ten years of symptomatic PD onset, and the mean time to depression was 7.9 years (median: 5.7 years). Factors associated with depression included longer PD duration, greater impairment in activities of daily living, and positive family history of motor neuron disease (MND).

Conclusions:

A high rate of individuals with PD develop depressive symptoms during the course of the disease. Based on first clinic visit characteristics, most factors examined were not helpful in identifying individuals with an increased risk of depression. However, disease duration, functional limitations and family history of MND should lead clinicians to an increased vigilance for identifying depression.

Objectif:

Le but de l’étude était d’examiner les facteurs de prédisposition pour la dépression chez les patients atteints de la maladie de Parkinson (MP).

Contexte:

La dépression peut précéder les symptômes de la MP ou apparaître au cours de l’évolution de la maladie. Il s’agit d’un problème traitable mais souvent ignoré.

Méthodes:

Nous avons étudié 685 individus, suivis par le même neurologue (RJU) entre 1994 et 2007, chez qui un diagnostic de MP avait été posé. L’issue primaire était le temps écoulé entre le début de la MP et l’installation de la dépression. Le diagnostic de dépression était basé sur l’évaluation clinique des symptômes dépressifs décrits par les patients (et l’épouse/la famille/le soignant) et la prise d’antidépresseurs. Certains facteurs démographiques, historiques et cliniques de prédisposition ont été examinés, dont le sexe, l’âge au moment du début des symptômes, la durée de la maladie, les manifestations au début de la maladie, les évaluations cliniques, la médication antiparkinsonienne, l’état cognitif, l’histoire antérieure de dépression et l’histoire familiale de MP ainsi que d’autres maladies neurodégénératives.

Résultats:

Soixante-douze pour cent des patients ont présenté une dépression au cours des dix années qui ont suivi le début des symptômes de la MP et le temps moyen écoulé depuis le début de la maladie était de 7,9 ans (médiane 5,7 ans). Les facteurs associés à la dépression étaient une durée d’évolution plus longue de la MP, un impact plus important sur les activités de la vie quotidienne et une histoire familiale positive de maladie du neurone moteur (MNM).

Conclusions:

Une proportion élevée de patients atteints de la MP éprouvent des symptômes de dépression au cours de la maladie. La plupart des facteurs examinés, parmi les observations notées à la première visite à la clinique, n’aidaient pas à identifier les individus à plus haut risque de dépression. Cependant, la durée de la maladie, les limites fonctionnelles et une histoire familiale de MNM devraient inciter les cliniciens à exercer plus de vigilance en ce qui concerne la dépression.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 37 , Issue 1 , January 2010 , pp. 61 - 66
Copyright
Copyright © The Canadian Journal of Neurological 2010

References

1. Reijnders, JS, Ehrt, U, Weber, WE, Aarsland, D, Leentjens, AF. A systematic review of prevalence studies of depression in Parkinson’s disease. Mov Disord. 2008;23(2):183–9; quiz 313.CrossRefGoogle ScholarPubMed
2. Tandberg, E, Larsen, JP, Aarsland, D, Cummings, JL. The occurrence of depression in Parkinson’s disease. A community-based study. Arch Neurol. 1996;53(2):175–9.Google Scholar
3. Cummings, JL. Depression and Parkinson’s disease: a review. Am J Psychiatry. 1992;149(4):443–54.Google Scholar
4. Nilsson, FM, Kessing, LV, Bolwig, TG. Increased risk of developing Parkinson’s disease for patients with major affective disorder: a register study. Acta Psychiatr Scand. 2001;104(5):380–6.CrossRefGoogle ScholarPubMed
5. Leentjens, AF, Van den Akker, M, Metsemakers, JF, Lousberg, R, Verhey, FR. Higher incidence of depression preceding the onset of Parkinson’s disease: a register study. Mov Disord. 2003;18(4):414–8.Google Scholar
6. Lemke, MR, Fuchs, G, Gemende, I, Herting, B, Oehlwein, C, Reichmann, H, et al. Depression and Parkinson’s disease. J Neurol. 2004;251 Suppl 6:VI/24–7.Google Scholar
7. Ravina, B, Camicioli, R, Como, PG, Marsh, L, Jankovic, J, Weintraub, D, et al. The impact of depressive symptoms in early Parkinson disease. Neurology. 2007;69(4):342–7.CrossRefGoogle ScholarPubMed
8. Weintraub, D, Moberg, PJ, Duda, JE, Katz, IR, Stern, MB. Effect of psychiatric and other nonmotor symptoms on disability in Parkinson’s disease. J Am Geriatr Soc. 2004;52(5):784–8.CrossRefGoogle ScholarPubMed
9. Cole, SA, Woodard, JL, Juncos, JL, Kogos, JL, Youngstrom, EA, Watts, RL. Depression and disability in Parkinson’s disease. J Neuropsychiatry Clin Neurosci. 1996;8(1):20–5.Google ScholarPubMed
10. Starkstein, SE, Mayberg, HS, Leiguarda, R, Preziosi, TJ, Robinson, RG. A prospective longitudinal study of depression, cognitive decline, and physical impairments in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1992;55(5):377–82.CrossRefGoogle ScholarPubMed
11. Kuopio, AM, Marttila, RJ, Helenius, H, Toivonen, M, Rinne, UK. The quality of life in Parkinson’s disease. Mov Disord. 2000;15(2):216–23.Google Scholar
12. Schrag, A, Jahanshahi, M, Quinn, N. What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatry. 2000;69(3):308–12.Google Scholar
13. Slawek, J, Derejko, M, Lass, P. Factors affecting the quality of life of patients with idiopathic Parkinson’s disease-a cross-sectional study in an outpatient clinic attendees. Parkinsonism Relat Disord. 2005;11(7):465–8.Google Scholar
14. Hughes, TA, Ross, HF, Mindham, RH, Spokes, EG. Mortality in Parkinson’s disease and its association with dementia and depression. Acta Neurol Scand. 2004;110(2):118–23.Google Scholar
15. Weintraub, D, Moberg, PJ, Duda, JE, Katz, IR, Stern, MB. Recognition and treatment of depression in Parkinson’s disease. J Geriatr Psychiatry Neurol. 2003;16(3):178–83.CrossRefGoogle ScholarPubMed
16. Shulman, LM, Taback, RL, Rabinstein, AA, Weiner, WJ. Non-recognition of depression and other non-motor symptoms in Parkinson’s disease. Parkinsonism Relat Disord. 2002;8(3):193–7.Google Scholar
17. Uitti, RJ, Baba, Y, Wszolek, ZK, Putzke, DJ. Defining the Parkinson’s disease phenotype: initial symptoms and baseline characteristics in a clinical cohort. Parkinsonism Relat Disord. 2005;11(3):139–45.Google Scholar
18. de Rijk, MC, Rocca, WA, Anderson, DW, Melcon, MO, Breteler, MM, Maraganore, DM. A population perspective on diagnostic criteria for Parkinson’s disease. Neurology. 1997;48(5):1277–81.Google Scholar
19. Ward, CD, Gibb, WR. Research diagnostic criteria for Parkinson’s disease. Adv Neurol. 1990;53:245–9.Google Scholar
20. Rodriguez-Oroz, MC, Gorospe, A, Guridi, J, Ramos, E, Linazasoro, G, Rodriguez-Palmero, M, et al. Bilateral deep brain stimulation of the subthalamic nucleus in Parkinson’s disease. Neurology. 2000;55(12 Suppl 6):S45–51.Google Scholar
21. Moro, E, Scerrati, M, Romito, LM, Roselli, R, Tonali, P, Albanese, A. Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson’s disease. Neurology. 1999;53(1):85–90.Google Scholar
22. Krause, M, Fogel, W, Heck, A, Hacke, W, Bonsanto, M, Trenkwalder, C, et al. Deep brain stimulation for the treatment of Parkinson’s disease: subthalamic nucleus versus globus pallidus internus. J Neurol Neurosurg Psychiatry. 2001;70(4):464–70.CrossRefGoogle ScholarPubMed
23. Fahn, S, Elton, RL. Unified Parkinson’s Disease Rating Scale. In: Fahn, S, Marsden, CD, Goldstein, M, Calne, D, editors. Recent developments in Parkinson’s disease, Volume 2. Florham Park, NJ: Macmillan; 1987. p. 153–63.Google Scholar
24. Hoehn, M, Yahr, M. Parkinsonism: onset, progression and mortality. Neurology. 1967;17:427–32.Google Scholar
25. Rojo, A, Aguilar, M, Garolera, MT, Cubo, E, Navas, I, Quintana, S. Depression in Parkinson’s disease: clinical correlates and outcome. Parkinsonism Relat Disord. 2003;10(1):23–8.Google Scholar
26. Schoevers, RA, Beekman, AT, Deeg, DJ, Geerlings, MI, Jonker, C, Van Tilburg, W. Risk factors for depression in later life; results of a prospective community based study (AMSTEL). J Affect Disord. 2000;59(2):127–37.Google Scholar
27. Beekman, AT, Deeg, DJ, van Tilburg, T, Smit, JH, Hooijer, C, van Tilburg, W. Major and minor depression in later life: a study of prevalence and risk factors. J Affect Disord. 1995;36(1-2):65–75.Google Scholar
28. Leentjens, AF, Lousberg, R, Verhey, FR. Markers for depression in Parkinson’s disease. Acta Psychiatr Scand. 2002;106(3):196–201.Google Scholar
29. Tandberg, E, Larsen, JP, Aarsland, D, Laake, K, Cummings, JL. Risk factors for depression in Parkinson disease. Arch Neurol. 1997;54(5):625–30.Google Scholar
30. Brown, RG, MacCarthy, B, Gotham, AM, Der, GJ, Marsden, CD. Depression and disability in Parkinson’s disease: a follow-up of 132 cases. Psychol Med. 1988;18(1):49–55.CrossRefGoogle ScholarPubMed
31. Palhagen, SE, Carlsson, M, Curman, E, Walinder, J, Granerus, AK. Depressive illness in Parkinson’s disease-indication of a more advanced and widespread neurodegenerative process? Acta Neurol Scand. 2008;117(5):295–304.Google Scholar
32. Chia, LG, Cheng, LJ, Chuo, LJ, Cheng, FC, Cu, JS. Studies of dementia, depression, electrophysiology and cerebrospinal fluid monoamine metabolites in patients with Parkinson’s disease. J Neurol Sci. 1995;133(1-2):73–8.Google Scholar
33. Cubo, E, Bernard, B, Leurgans, S, Raman, R. Cognitive and motor function in patients with Parkinson’s disease with and without depression. Clin Neuropharmacol. 2000;23(6):331–4.Google Scholar
34. Houde, SC, Mangolds, V. Amyotrophic lateral sclerosis: a team approach to primary care. Clin Excell Nurse Pract. 1999;3(6):337–45.Google Scholar
35. Oertel, WH, Hoglinger, GU, Caraceni, T, Girotti, F, Eichhorn, T, Spottke, AE, et al. Depression in Parkinson’s disease. An update. Adv Neurol. 2001;86:373–83.Google ScholarPubMed
36. Tom, T, Cummings, JL. Depression in Parkinson’s disease. Pharmacological characteristics and treatment. Drugs Aging. 1998;12(1):55–74.Google Scholar
37. Mayeux, R, Stern, Y, Rosen, J, Leventhal, J. Depression, intellectual impairment, and Parkinson disease. Neurology. 1981;31(6):645–50.Google Scholar
38. Wichowicz, HM, Slawek, J, Derejko, M, Cubala, WJ. Factors associated with depression in Parkinson’s disease: a cross-sectional study in a Polish population. Eur Psychiatry. 2006;21(8):516–20.Google Scholar
39. Marsh, L, McDonald, WM, Cummings, J, Ravina, B. Provisional diagnostic criteria for depression in Parkinson’s disease: report of an NINDS/NIMH Work Group. Mov Disord. 2006;21(2):148–58.Google Scholar