Hostname: page-component-848d4c4894-sjtt6 Total loading time: 0 Render date: 2024-07-05T06:04:27.010Z Has data issue: false hasContentIssue false
  • English
  • Français

Cross Correlation Studies in Primate Motor Cortex: Synaptic Interaction and Shared Input

Published online by Cambridge University Press:  18 September 2015

John T. Murphy ,
Hon C. Kwan  and
Yiu C. Wong
John T. Murphy*
Affiliation:
Departments of Physiology and Medicine, University of Toronto
Hon C. Kwan*
Affiliation:
Departments of Physiology and Medicine, University of Toronto
Yiu C. Wong*
Affiliation:
Departments of Physiology and Medicine, University of Toronto
*
11–241 Eaton North, Toronto General Hospital, 101 College Street, Toronto, Ontario, Canada M5G 1L7
11–241 Eaton North, Toronto General Hospital, 101 College Street, Toronto, Ontario, Canada M5G 1L7
11–241 Eaton North, Toronto General Hospital, 101 College Street, Toronto, Ontario, Canada M5G 1L7
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Awake, unrestrained monkeys were trained to reach out with the forelimb and touch a button. Extracellular spike trains were recorded from pairs of neurons in contralateral precentral cortex with the same or separate microelectrodes. The neurons were located in the same or different functional columns as defined by intracortical microstimulation and passive sensory stimulation. Cross correlation analysis showed patterns consistent with synaptic excitation and/or inhibition between members of the cell pairs during the voluntary movement. The strength of correlation was inversely related to distance between columns, with the strongest correlations found between cells within the same column. Inhibitory correlations were virtually restricted to cell pairs within a single column. Temporal analysis showed that direct synaptic interaction and shared input patterns could be clearly distinguished in this physiologic setting. Spatial analysis indicated that shared input was concentrated among columns in the same and adjacent joint controlling zones as well as within a single column. No directional preference of shared input was present, a finding which was consistent with the observed nested organization of the forelimb area.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 12 , Issue 1 , February 1985 , pp. 11 - 23
Copyright
Copyright © Canadian Neurological Sciences Federation 1985

References

Allum, JHJ, Hepp, RMC and Gysin, R (1982) Cross correlation analysis of interneuronal connectivity in the motor cortex of the monkey. Brain Research, 231: 325–334.CrossRefGoogle ScholarPubMed
Asanuma, H and Rosen, I (1973) Spread of mono- and polysynaptic connections within cat motor cortex. Exp Brain Res 16: 507–520.CrossRefGoogle Scholar
Dickson, JW and Gerstein, GL (1974) Interactions between neurons in auditory cortex of the cat. J Neurophysiol 37: 1239–1261.CrossRefGoogle ScholarPubMed
Fetz, EE and Cheney, PD (1978) Muscle fields of primate corticomotorneuronal cells. J Physiol (Paris) 74: 239–245.Google Scholar
Gatter, KC and Powell, TPS (1978) The intrinsic connections of the cortex of area 4 of the monkey. Brain 101: 513–542.CrossRefGoogle ScholarPubMed
Harnett, DL (1975). Introduction to statistical methods. 2nd Ed. Addison-Wesley, Mass., pp 529–532.Google Scholar
Humphrey, DR (1979) On the cortical control of visually directed reaching: Contributions by non-precentral motor areas. In: Posture and Movement, Talbot, RE and Humphrey, DR (eds). Raven Press, N.Y.Google Scholar
Jones, EG (1983) Thalamic basis for column-like input to monkey somatic sensory and motor cortex. In: Somatosensory Integration in the Thalamus. Macchi, G et al (eds). Elsevier, Amsterdam, pp 309–336.Google Scholar
Jones, EG, Coulter, JD and Hendry, SHC (1978) Intracortical connectivity of architectonic fields in the somatic sensory, motor and parietal cortex of monkeys. J Comp Neur 181: 291–348.CrossRefGoogle ScholarPubMed
Jones, EG, Coulter, JD and Wise, SP (1979) Commissural columns in the sensory-motor cortex of monkeys. J Comp Neur 188: 113–136.CrossRefGoogle ScholarPubMed
Jones, EG and Wise, SP (1977) Size, laminar and columnar distribution of efferent cells in the sensory motor cortex of monkeys. J Comp Neurol 175: 391–438.CrossRefGoogle ScholarPubMed
Kelly, JS and Renaud, LP (1974) Physiologic identification of inhibitory interneurons in the feline pericruciate cortex. Neuropharmacology 13: 463–474.CrossRefGoogle ScholarPubMed
Knox, CK (1981) Detection of neuronal interactions using correlation analysis. TINS 4: 222–225.Google Scholar
Kwan, HC, MacKay, WA, Murphy, JT and Wong, YC (1978) Organization of precentral cortex in awake primates. II Motor outputs. J Neurophysiol 41: 1120–1131.CrossRefGoogle ScholarPubMed
Kwan, HC, MacKay, WA, Murphy, JT and Wong, YC (1980) Recordings of simultaneous spike trains by two independent electrodes in awake primates. Physiol and Behav 25: 321–322.CrossRefGoogle ScholarPubMed
Kwan, HC, MacKay, WA, Murphy, JT and Wong, YC (1981) Distribution of responses to visual cues for movement in precentral cortex of awake primates. Neurosci Lett 24: 123–128.CrossRefGoogle ScholarPubMed
Lamarre, Y, Spidaliri, G and Lund, JP (1981) Patterns of muscular and motor cortical activity during a simple arm movement in the monkey. Am J Physiol Pharmacol 59: 748–756.CrossRefGoogle ScholarPubMed
Mastronade, DN (1983) Correlated firing of cat retinal ganglion cells. I Spontaneously active inputs to x- and y-cells. J Neurophysiol 49: 303–324.Google Scholar
Matsumura, M (1979) Intracellular synaptic potentials of primate motor cortex neurons during voluntary movement. Brain Research 163: 33–48.CrossRefGoogle ScholarPubMed
Michalski, A, Gerstein, GL, Garkowska, J and Tarnecki, R (1983) Interactions between cat striate cortex neurons. Exptl Brain Res 51: 97–107.Google Scholar
Moore, GP, Segundo, JP, Perkel, DH and Levitan, H (1970) Statistical signs of synaptic interaction in neurons. Biophys J 10: 876–900.CrossRefGoogle ScholarPubMed
Murphy, JT, Kwan, HC, MacKay, WA and Wong, YC (1978) Spatial organization of precentral cortex in awake primates. III. Input-output coupling. J Neurophysiol 41: 1132–1139.Google ScholarPubMed
Murphy, JT, Kwan, HC and Wong, YC (1985a) Cross correlation studies in primate motor cortex. II. Event related correlation. Can J Neurol SciGoogle ScholarPubMed
Murphy, JT, Kwan, HC and Wong, YC (1985b). Sequential activation of neurons in primate motor cortex during unrestrained forelimb movement. J Neurophysiology, in press.CrossRefGoogle ScholarPubMed
Murphy, JT, Kwan, HC, MacKay, WA and Wong, TC (1982a) Activity of primate precentral neurons during voluntary movements triggered by visual signals. Brain Research 236: 429–449.CrossRefGoogle ScholarPubMed
Murphy, JT, Kwan, HC, MacKay, WA and Wong, YC (1982b) Precentral unit activity correlated with angular components of a compound movement. Brain Research 246: 141–145.CrossRefGoogle Scholar
Perkel, DH, Gerstein, GL and Moore, GP (1967) Neuronal spike trains and stochastic point processes. II. Simultaneous spike train. Biophys J 7: 419–440.CrossRefGoogle Scholar
Perkel, DH, Gerstein, GL, Smith, MS and Tatton, WG (1975) Nerve-impulse patterns: Aquantitative display technique forthree neurons. Brain Research 100: 271–296.CrossRefGoogle Scholar
Phillips, CG (1981) Microarchitecture of motor cortex of primates. In: Progress in Anatomy, Vol 1. Harrison, RJ and Holmes, RL (eds). Cambridge University Press, Cambridge, pp. 61–94.Google Scholar
Rosenthal, F (1972) Extracellular potential fields of single PT-neurons. Brain Res 36: 251–263.CrossRefGoogle ScholarPubMed
Sabah, NH and Murphy, JT (1971) A superposition model of the spontaneous synaptic excitation of cerebellar Purkinje cells. Biophys J 11:414–428.CrossRefGoogle Scholar
Sears, TA and Stagg, D.Short-term synchronization of intercostal motorneuron activity. J Physiol (London) 263: 357–381.CrossRefGoogle Scholar
Soechting, JF (1984) Effect of target size on spatial and temporal characteristics of a pointing movement in man. Expt Brain Res 54: 121–132.Google ScholarPubMed
Stoney, SD, Thompson, WD and Asanuma, H (1968) Excitation of pyramidal tract cells by intracortical microstimulation: effective extent of stimulating current. J Neurophysiol 31: 659–669.CrossRefGoogle ScholarPubMed
Strick, PL (1976a) Anatomical analysis of ventrolateral thalamic input to primate motor cortex. J Neurophysiol 39: 1020–1031.CrossRefGoogle ScholarPubMed
Strick, PL (1976b) Activity of ventrolateral thalamic neurons during arm movement. J Neurophysiol 39: 1032–1044.CrossRefGoogle ScholarPubMed
Szentagothai, J (1978) The neuron network of the cerebral cortex. A functional interpretation. Proc R Soc Lond Ser B 201: 219–248.Google ScholarPubMed
Tatton, WG and Sokolove, PG (1975) Analysis of postural motoneuron activity in crayfish abdomen. 11. Co-ordination by excitatory and inhibitory connections between motoneurons. J Neurophysiol 38: 332–346.CrossRefGoogle Scholar
Von Neumann, J (1956) Probabilistic logics and the synthesis of reliable organisms from unreliable components. In: Automata Studies, Shannon, CE and McCarthy, J (eds), Princeton University Press, Princeton, pp 43–98.Google Scholar
Wong, YC, Kwan, HC, MacKay, WA and Murphy, JT (1978) Spatial organization of precentral cortex in awake primates. I. Somatosensory inputs. J Neurophysiol 41: 1107–1119.CrossRefGoogle ScholarPubMed
Wong, YC, Kwan, HC and Murphy, JT (1980) Temporal characteristics of torque-triggered neuronal responses in primate precentral cortex. Can J Physiol Pharmacol 58: 778–786.CrossRefGoogle Scholar