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Concurrence of glioma and multiple sclerosis

Published online by Cambridge University Press:  02 December 2014

Shah-Naz Hayat Khan ,
Joseph E. Buwembo  and
Q. Li
Shah-Naz Hayat Khan*
Affiliation:
Division of Neurosurgery, Department of Surgery, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Joseph E. Buwembo
Affiliation:
Section of Neurosurgery, Department of Surgery, Regina General Hospital, Regina, Saskatchewan, Canada
Q. Li
Affiliation:
Department of Pathology, Regina General Hospital, Regina, Saskatchewan, Canada
*
Division of Neurosurgery, Department of Surgery, 103 Hospital Drive, Royal University Hospital, Saskatoon, Saskatchewan, S7N 0W8, Canada
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A 29-year-old Caucasian female diagnosed with multiple sclerosis (MS) for seven years, presented with a history of headaches and a single episode of new onset seizures. Her physical examination was unremarkable and she was placed on anti-seizure medications. A computed tomography (CT) scan showed a right frontal brain lesion causing minimal mass effect (Figure 1). Magnetic resonance imaging (MRI) revealed a large nonenhancing space occupying lesion in the right frontal lobe, in addition to numerous smaller lesions which were characteristic of MS plaques (Figures 2 & 3). The large lesion was causing mass effect with right to left midline shift (Figures 2, 3A & B). Given the patient’s history, the appearance and unusually large size of the frontal lesion, it was unclear whether it was a demyelinating MS plaque, or an intra-axial tumour.

Type
Neuroimaging Highlight
Information
Canadian Journal of Neurological Sciences , Volume 32 , Issue 3 , August 2005 , pp. 349 - 351
Copyright
Copyright © The Canadian Journal of Neurological 2005

References

1. Green, AJ, Bollen, AW, Berger, MS, Oksenberg, JR, Hauser, SL. Multiple sclerosis and oligodendroglioma. Mult Scler 2001;7:269–273.Google Scholar
2. Paydarfar, D, de la Monte, SM. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 121997. A 50-year-old woman with multiple sclerosis and an enlarging frontal-lobe mass. N Engl J Med 1997;336:1163–1171.Google Scholar
3. Kumar, K, Toth, C, Jay, V. Focal plaque of demyelination mimicking cerebral brain tumor in a pediatric patient. Pediatr Neurosurg 1998;29:60–63.Google Scholar
4. Barkhof, F, Filippi, M, Miller, D, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997;120:2059–2069.Google Scholar
5. Hershey, LA, Gado, MH, Trotter, JL. Computed tomography in diagnostic evaluation of multiple sclerosis. Ann Neurol 1979;5:32–39.Google Scholar
6. Brant-Zawadzki, M, Berry, I, Osaki, L, et al. Gd- DTPA in clinical MR of the brain: 1. Intraaxial lesions. AJR Am J Roentgend 1986;147:1223–1230.Google Scholar
7. Butteriss, DJ, Ismail, A, Ellison, DW, Birchall, D. Use of serial proton magneticresonance spectroscopy to differentiate low grade glioma from tumefactive plaque in a patient with multiple sclerosis. Br J Radiol 2003;76:662–665.Google Scholar
8. Takano, T, Lin, JH, Arcuino, G, et al. Glutamate release promotes growth of malignant gliomas. Nat Med 2001;7:1010–1015.Google Scholar
9. Kaye, AH, Walker, DG. Low-grade glial neoplasms. In: Batjer, HH, Loftus, CM (Eds). Textbook of Neurological Surgery. Philadelphia: Lippincott Williams & Wilkins, 2003:1257–1270.Google Scholar
10. Fortin, D, Cairncross, GJ, Hammond, RR. Oligodendroglioma: an appraisal of recent data pertaining to diagnosis and treatment. Neurosurgery 1999;45:1279–1291.Google Scholar