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Cerebrovascular Permeability in Mechanically Induced Hypertension

Published online by Cambridge University Press:  18 September 2015

Sukriti Nag ,
David M. Robertson  and
Henry B. Dinsdale
Sukriti Nag*
Affiliation:
Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital, Kingston, Ontario, Canada
David M. Robertson
Affiliation:
Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital, Kingston, Ontario, Canada
Henry B. Dinsdale
Affiliation:
Departments of Pathology and Medicine, Queen’s University and Kingston General Hospital, Kingston, Ontario, Canada
*
Department of Pathology, Queen’s University, Kingston, Ontario, Canada K7L 3N6
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Our previous studies of cerebrovascular permeability in angiotensin-induced acute hypertension demonstrated that the principal mechanism resulting in increased permeability is enhanced pinositose. In order to exclude the possibility that the enhanced pinositose was a direct effect of exogenous angiotensin, cerebrovascular permeability alterations were studied in nonpharmacologically induced acute hypertension.

Rats receiving horseradish peroxidase (HRP) intravenously, were sacrificed 2½ minutes after the onset of hypertension induced by placing a clip on the abdominal aorta. These animals showed the same pattern of permeability alterations as had been observed previously in animals with angiotensin-induced acute hypertension. Focal segments of penetrating arterioles in the temporal and parietal cortex showed increased permeability to HRP. Permeable vessels showed increased numbers of pinocytotic vesicles and the interendothelial junctions revealed no alterations. Enhanced pinocytosis appears to be the principal mechanism resulting in increased cerebrovascular permeability in this model as well suggesting that the alterations of cerebrovascular permeability observed previously in angio-tensin-induced acute hypertension occur due to the hypertensive state and are not a direct drug effect of exogenous angiotensin.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 8 , Issue 3 , August 1981 , pp. 215 - 220
Copyright
Copyright © Canadian Neurological Sciences Federation 1981

References

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