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Cerebrospinal Fluid and Blood Thiamine Concentrations in Phenytoin-Treated Epileptics

Published online by Cambridge University Press:  18 September 2015

M.I. Botez ,
Claude Joyal ,
Urs Maag  and
Jocelyne Bachevalier
M.I. Botez*
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
Claude Joyal
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
Urs Maag
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
Jocelyne Bachevalier
Affiliation:
Service of Neurology, Hôtel-Dieu Hospital and Clinical Research Institute of Montreal and Department of Computer Sciences and Operation Research, University of Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Québec H2W 1R7, Canada
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Summary:

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Thiamine and folate levels in blood and cerebrospinal fluid (CSF) were determined by microbiological assays in 23 control subjects and 11 phenytoin-treated epileptics. There was no significant difference between the two groups for serum and CSF folate levels. There was, however, a statistically significant difference between the groups for both whole blood thiamine and CSF thiamine levels. Epileptic patients being treated with phenytoin had lower values than control subjects (p < 0.001)

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 9 , Issue 1 , February 1982 , pp. 37 - 39
Copyright
Copyright © Canadian Neurological Sciences Federation 1982

References

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