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Cerebral Metastases from Malignant Melanoma

Published online by Cambridge University Press:  18 September 2015

Ivar M. Mendez  and
Rolando F. Del Maestro
Ivar M. Mendez
Affiliation:
Brain Research Laboratories, Clinical Research Unit, Department of Clinical Neurological Sciences, Victoria Hospital, London
Rolando F. Del Maestro*
Affiliation:
Brain Research Laboratories, Clinical Research Unit, Department of Clinical Neurological Sciences, Victoria Hospital, London
*
Brain Research Laboratory, Victoria Hospital, 375 South Street, London, Ontario, Canada N6A 4G5
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Abstract:

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Six hundred and fifty-two patients with histologically proven primary malignant melanoma have been followed by the London Regional Cancer Centre from 1960 to 1985. Neurological signs and symptoms secondary to metastases to the brain developed in fifty-five patients (8.4%). The median age was 49 years; 71% were male and 29% female. Multiple lesions were found in 61% and a single metastasis in 39%. The most common site for the primary lesion was the trunk in males (44%) and the lower limb in females (37%). Six month survival for patients with a single metastasis was 58% if surgical excision was possible and 25% of these patients survived greater than two years. In patients with multiple metastases that received radiotherapy, survival times of greater than six months were found in 12% of the patients. Patients with a single metastasis appear to benefit by being managed by surgical removal of the lesion.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 15 , Issue 2 , May 1988 , pp. 119 - 123
Copyright
Copyright © Canadian Neurological Sciences Federation 1988

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