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Can Admission S-100β Predict the Extent of Brain Damage in Head Trauma Patients?

Published online by Cambridge University Press:  02 December 2014

E. Schültke ,
V. Sadanand ,
M.E. Kelly ,
R.W. Griebel  and
B.H.J. Juurlink
E. Schültke*
Affiliation:
Departments of Anatomy & Cell Biology and Surgery, University of Saskatchewan, Saskatoon, Canada Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
V. Sadanand
Affiliation:
Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
M.E. Kelly
Affiliation:
Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
R.W. Griebel
Affiliation:
Division of Neurosurgery, University of Saskatchewan, Saskatoon, Canada
B.H.J. Juurlink
Affiliation:
Departments of Anatomy & Cell Biology and Surgery, University of Saskatchewan, Saskatoon, Canada College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia
*
A 302 Health Sciences Building, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada
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Abstract

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Background:

As has been shown previously, S-100β levels in serum can be a useful predictor of brain damage after head trauma. This pilot study was designed to investigate whether urine samples, which are much easier to obtain, could be used for the same purpose instead of serum samples.

Methods:

Ninety-six consecutive patients admitted with head trauma were recruited in the study. After exclusion of 54 patients, mostly because of significant additional trauma, S-100β levels were analyzed in serum and urine of 42 patients using a luminometric assay. A range for normal values was established based on samples from ten healthy volunteers.

Results:

S-100β serum levels increased proportional to the severity of the head trauma, as had been previously shown by several other groups. In many patients, initial increases in urine S-100β levels were seen later than in serum, after which the kinetics of S-100β levels in urine seemed to follow that established for serum levels. S-100β values in urine were on average about 54% lower in urine than in serum.

Conclusions:

S-100β levels in urine obtained on admission to the hospital are not a good indicator for the extent of brain damage. However, urine S-100β levels obtained at later time points might be a useful indicator for the development of secondary brain injury.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 36 , Issue 5 , September 2009 , pp. 612 - 616
Copyright
Copyright © The Canadian Journal of Neurological 2009

References

1.Tei, I, Koh, E, Yokoyama, S.Clinical study of serum S-100β protein as marker of brain injury in cardiovascular surgery. Kyobu Geka. 1999;52(13):1090–4.Google Scholar
2.Georgiadis, D, Berger, A, Kowatschev, E, Lautenschläger, C, Börner, A, Lindner, A, et al.Predictive value of S-100β and neuronspecific enolase serum levels for adverse neurologic outcome after cardiac surgery. J Thorac Cardiovasc Surg. 2000;119(1): 138–47.Google Scholar
3.Missler, U, Wiesmann, M, Friedrich, C, Kaps, M.S-100 protein and neuron-specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke. 1997;28(10):1956–60.Google Scholar
4.Martens, P, Raabe, A, Johnsson, P.Serum S-100 and neuron-specific enolase for prediction of regaining consciousness after global cerebral ischemia. Stroke. 1998;29(11):2363–6.Google Scholar
5.Raabe, A, Grolms, C, Keller, M, Döhnert, J, Sorge, O, Seifert, V.Correlation of computed tomography findings and serum brain damage markers following severe head injury. Acta Neurochir. (Wien) 1998;140(8):791–2.Google Scholar
6.Ingebrigtsen, T, Waterloo, K, Jacobsen, EA, Langbakk, B, Romner, B.Traumatic brain damage in minor head injury: relation of serum S-100 protein measurements to magnetic resonance imaging and neurobehavioral outcome. Neurosurgery. 1999;45(3):475–6.CrossRefGoogle ScholarPubMed
7.Woertgen, C, Rothoerl, RD, Metz, C, Brawanski, A.Comparison of clinical, radiologic and serum marker as prognostic factors after severe head injury. J Trauma. 1999;47(6):1126–30.Google Scholar
8.Herrmann, M, Jost, S, Kutz, S, Ebert, AD, Kratz, T, Wunderlich, MT, et al.Temporal profile of release of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computerized tomography. J Neurotrauma. 2000;17(2):113–22.Google Scholar
9.Romner, B, Ingebrigtsen, T, Kongstad, P, Borgesen, SE.Traumatic brain damage: serum S-100 protein measurements related to neuroradiological findings. J Neurotrauma. 2000;17(8):641–7.CrossRefGoogle ScholarPubMed
10.Poli-de-Figueiredo, LF, Biberthaler, P, Simao Filho, C, Hauser, C, Mutschler, W, Jochum, M.Measurement of S-100β for risk classification of victims sustaining minor head injury-first pilot study in Brazil. Clinics. 2006;61(1):41–6.Google Scholar
11.Savola, O, Hillbom, M.Early predictors of post-concussion symptoms in patients with mild head injury. Eur J Neurol. 2003;10(2):175–81.Google Scholar
12.Stapert, S, de Kruijk, J, Houx, P, Menheere, P, Twijnstra, A, Jolles, J.S-100β concentration is not related to neurocognitive performance in the first month after mild traumatic brain injury. Eur Neurol. 2005;53(1):22–6.CrossRefGoogle Scholar
13.Woertgen, C, Rothoerl, RD, Holzschuh, M, Metz, C, Brawanski, A.Comparison of serial S-100 and NSE serum measurements after severe head injury. Acta Neurochir. (Wien) 1997;139(12):1161–65.Google Scholar
14.Rothoerl, RD, Woertgen, C, Holzschuh, M, Metz, C, Brawanski, A.S-100 serum levels after minor and major head injury. J Trauma. 1998;45(4):765–7.CrossRefGoogle ScholarPubMed
15.Raabe, A, Grolms, C, Sorge, O, Zimmermann, M, Seifert, V.Serum S-100 protein in severe head injury. Neurosurgery. 1999;45(3):477–83.CrossRefGoogle ScholarPubMed
16.Raabe, A, Grolms, C, Seifert, V.Serum markers of brain damage and outcome prediction in patients after severe head injury. Br J Neurosurg. 1999;13(1):56–9.Google Scholar
17.Raabe, A, Seifert, V.Fatal secondary increase in serum S-100β protein after severe head injury. Report of three cases. J Neurosurg. 1999;91(5):875–7.CrossRefGoogle Scholar
18.Petzold, A, Green, AJ, Keir, G, Fairley, S, Kitchen, N, Smith, M, et al.Role of serum S100β as an early predictor of high intracranial pressure and mortality in brain injury: a pilot study. Crit Care Med. 2002;30(12):2705–10.Google Scholar
19.Raabe, A, Kopetsch, O, Woszczyk, A, Lang, J, Gerlach, R, Zimmermann, M, et al.Serum S-100β protein as a molecular marker in severe traumatic brain injury. Restor Neurol Neurosci. 2003;21(3-4):15.Google ScholarPubMed
20.Regner, A, Kaufman, M, Friedman, G, Chemale, I.Increased serum S100β protein concentrations following severe head injury in humans: a biochemical marker of brain death? Neuroreport. 2001;12(4):691–4.Google Scholar
21.da Rocha, AB, Schneider, RF, de Freitas, GR, André, C, Grivicich, I, Zanoni, C, et al.Role of serum S100β as a predictive marker of fatal outcome following isolated severe head injury or multitrauma in males. Clin Chem Lab Med. 2006;44(10):1234–42.CrossRefGoogle ScholarPubMed
22.Shiraishi, N, Nishikimi, M.Suppression of copper-induced cellular damage by copper sequestration with S100β protein. Arch Biochem Biophys. 1998;357(2):225–30.Google Scholar
23.Savola, O, Pyhtinen, J, Leino, TK, Siitonen, S, Niemelä, O, Hillbom, M.Effects of head and extracranial injuries on serum protein S100β levels in trauma patients. J Trauma. 2004 Jun; 56(6):1229–34.Google Scholar
24.Anderson, RE, Hansson, LO, Nilsson, O, Dijlai-Merzoug, R, Settergren, G.High serum S100β levels for trauma patients without head injuries. Neurosurgery. 2001;48(6):1255–8.Google Scholar
25.Hasselblatt, M, Mooren, FC, von Ahsen, N, Keyvani, K, Fromme, A, Schwarze-Eicker, K, et al.Serum S100beta increases in marathon runners reflect extracranial release rather than glial damage. Neurology. 2004;62(9):1634–6.Google Scholar
26.Ytrebø, LM, Nedredal, GI, Korvald, C, Holm Nielsen, OJ, Ingebrigtsen, T, Romner, B, et al.Renal elimination of protein S-100β in pigs with acute encephalopathy. Scand J Clin Lab Invest. 2001;61: 217–26.Google Scholar
27.Berger, RP, Kochanek, PM.Urinary S100β concentrations are increased after brain injury in children: A preliminary study. Pediatr Crit Care Med. 2006;7(6):557–61.CrossRefGoogle Scholar
28.Hallén, M, Carlhed, R, Karlsson, M, Hallgren, T, Bergenheim, M.A comparison of two different assays for determining S-100β in serum and urine. Clin Chem Lab Med. 2008;46(7):1025–9.Google Scholar