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Blood Flow Differences Between Leuko-araiosis with and without Lacunar Infarction

Published online by Cambridge University Press:  18 September 2015

Minoru Oishi ,
Yoko Mochizuki  and
Toshiaki Takasu
Minoru Oishi*
Affiliation:
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan
Yoko Mochizuki
Affiliation:
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan
Toshiaki Takasu
Affiliation:
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan
*
Department of Neurology, Nihon University, Nerima Hikarigaoka Hospital, 2-11-1 Hikarigaoka, Nerima-ku, Tokyo 179, Japan
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Abstract:

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Background:

The present study was designed to find the differences in regional cerebral blood flow and cerebrovascular acetazolamide reactivity between leuko-araiosis with and without lacunar infarction.

Methods:

Fifteen cases of leuko-araiosis with lacunar infarction, 15 cases of leuko-araiosis without lacunar infarction and 15 age-matched controls in which leuko-araiosis and cerebrovascular diseases are absent (control group) were studied. The regional cerebral blood flow was measured using the stable xenon computed tomography method before and 20 minutes after intravenous injection of 17 mg/kg acetazolamide.

Results:

The blood flows in the leuko-araiosis area and the lacunar area were significantly lower than the blood flow in the cerebral white matter. The blood flows in the cerebral cortex and the cerebral white matter were significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group. The cerebrovascular acetazolamide reactivity in the leuko-araiosis area and the lacunar area was significantly lower than that in the cerebral white matter. The cerebrovascular acetazolamide reactivity in the cerebral cortex and the cerebral white matter was significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group.

Conclusions:

The degree of arteriolosclerosis is considered to be more severe and the rate of association of hypertension was higher in leuko-araiosis with lacunar infarction than in leuko-araiosis without lacunar infarction.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 25 , Issue 1 , February 1998 , pp. 70 - 75
Copyright
Copyright © Canadian Neurological Sciences Federation 1998

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