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Astrocytoma Following Scalp Radiotherapy in Infancy

Published online by Cambridge University Press:  18 September 2015

Douglas W. Zochodne ,
J. Gregory Cairncross ,
Felix P. Arce ,
John C.F. MacDonald ,
Warren T. Blume ,
John P. Girvin  and
John C.E. Kaufmann
Douglas W. Zochodne
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
J. Gregory Cairncross*
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
Felix P. Arce
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
John C.F. MacDonald
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
Warren T. Blume
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
John P. Girvin
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
John C.E. Kaufmann
Affiliation:
the Departments of Clinical Neurological Sciences, Pathology (Neuropathology) and Radiation Oncology, University of Western Ontario, London, Canada, and Ontario Cancer Treatment and Research Foundation
*
391 South Street, London, Ontario, Canada N6A 4G5
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Abstract

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A 24 year old woman with a 15 year history of intractable seizures underwent resection of a small low grade astrocytoma of the right mesial frontal lobe. The tumor arose beneath a benign scalp nevus that had been treated in infancy with radium patches and focal x-irradiation. Neuropathological changes within the tumor were compatible with radiation injury. Meningiomas and sarcomas complicate cranial irradiation but the evidence that gliomas do so is less convincing. Our observations support an association between radiation exposure and the subsequent development of glial tumors.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 4 , November 1984 , pp. 475 - 478
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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