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Anticoagulation in Cerebral Embolism

Published online by Cambridge University Press:  18 September 2015

Edward Bass
Edward Bass*
Affiliation:
Department of Neurosciences, Sir Mortimer B. Davis Jewish General Hospital, Montreal, Quebec
*
Department of Internal Medicine, Division of Neurology, Box 19, University of South Florida, 12901 North 30th Street, Tampa, Florida 33612.
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Summary:

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A case of presumed anticoagulant induced hemorrhage into infarction is presented along with a retrospective study of 110 cases of cerebral embolus.

An accurate recommendation for the timing of anticoagulation following cerebral embolism hinges on balancing the risk of hemorrhage into infarction against the benefits of early treatment attributed to preventing recurrent embolism. It is felt that the present literature, concepts of pathogenesis and experimental data provide insufficient information to make absolute clinical decisions. The available evidence implies that the risk of further embolic events is three to four times that of hemorrhage into infarction, yet additional randomized prospective studies and better experimental models are needed to establish a valid treatment plan. It may be possible to distinguish separate mechanisms underlying early diffuse hemorrhage into infarction from sudden delayed massive hematoma formation.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 10 , Issue 1 , February 1983 , pp. 32 - 36
Copyright
Copyright © Canadian Neurological Sciences Federation 1983

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