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Action of 5-Hydroxytryptamine, Substance P, Thyrotropin-Releasing Hormone and Clonidine on Motoneurone Excitability

Published online by Cambridge University Press:  05 January 2016

Paul J. Bédard ,
L.E. Tremblay ,
H. Barbeau ,
M. Filion ,
R. Maheux ,
C.L. Richards  and
T. DiPaolo
Paul J. Bédard*
Affiliation:
Laboratoire de Neurobiologie, Faculté de Médicine, Université Laval, Québec
L.E. Tremblay
Affiliation:
Laboratoire de Neurobiologie, Faculté de Médicine, Université Laval, Québec
H. Barbeau
Affiliation:
Laboratoire de Neurobiologie, Faculté de Médicine, Université Laval, Québec
M. Filion
Affiliation:
Laboratoire de Neurobiologie, Faculté de Médicine, Université Laval, Québec
R. Maheux
Affiliation:
Laboratoire de Neurobiologie, Faculté de Médicine, Université Laval, Québec
C.L. Richards
Affiliation:
Laboratoire de Neurobiologie, Faculté de Médicine, Université Laval, Québec
T. DiPaolo
Affiliation:
Département d'endocrinologie moléculaire, Centre Hospitalier de l'Université Laval, Québec
*
Laboratoire de Neurobiologie, Hôpital de l'Enfant-Jésus, 1401, 18e Rue, Québec, Québec, Canada GIJ 1Z4
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Abstract:

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We have investigated the influence on the excitability of lumbar motoneurons of 5-hydroxytryptamine (5-HT), substance P and thyrotropin releasing hormone (TRH), three substances which coexist in the same bulbospinal descending pathway and end in large part around motoneurons. We have also studied the effect of clonidine, an alpha 2 noradrenergic agonist. This was done in spinalized rats (T5) treated three weeks before with 5-7-dihydroxytryptamine. Under those circumstances 5-HTP (LP.), 5-HT (intrathecally) TRH (LP. or I.T.) and substance P (I.T.) all elicited a strong excitation of motoneurons as measured by integrated EMG of the hindlimb muscles. Substance P reduced by almost half the subsequent response to 5-HTP, 1 hour and 24 hours later. TRH given acutely did not modify the response to 5-HTP but given chronically for twenty one days by means of Alzet minipump, markedly increased the response to 5-HTP. Clonidine by itself decreased the excitability of motoneurons and antagonized the excitatory effect of 5-HTP and TRH. In a pilot trial, cyproheptadine, a 5-HT antagonist was shown to decrease the manifestations of spasticity in patients with a partial spinal lesion. Clonidine also appears to be of potential use in the treatment of spasticity.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue S3 , August 1987 , pp. 506 - 509
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

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