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18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans

Published online by Cambridge University Press:  18 September 2015

E.G. McGeer ,
R.P. Peppard ,
P.L. McGeer ,
H. Tuokko ,
D. Crockett ,
R. Parks ,
H. Akiyama ,
D.B. Calne ,
B.L. Beattie  and
R. Harrop
E.G. McGeer*
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, Burnaby, British Columbia
R.P. Peppard
Affiliation:
Division of Neurology, Department of Medicine, Burnaby, British Columbia
P.L. McGeer
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, Burnaby, British Columbia
H. Tuokko
Affiliation:
Department of Psychology, University Hospital, Burnaby, British Columbia
D. Crockett
Affiliation:
Division of Psychology, Department of Psychiatry, Burnaby, British Columbia
R. Parks
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, Burnaby, British Columbia Division of Psychology, Department of Psychiatry, Burnaby, British Columbia
H. Akiyama
Affiliation:
Kinsmen Laboratory of Neurological Research, Department of Psychiatry, Burnaby, British Columbia
D.B. Calne
Affiliation:
Division of Neurology, Department of Medicine, Burnaby, British Columbia
B.L. Beattie
Affiliation:
Department of Medicine, University of B.C., Burnaby, British Columbia
R. Harrop
Affiliation:
Vancouver, and School of Computer Science, Simon Fraser University, Burnaby, British Columbia
*
2255 Wesbrook Mall, University of B.C., Vancouver, British Columbia, Canada V6T 1W5
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Abstract:

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Positron emission tomographic (PET) data on local cerebral metabolic rates for glucose (LCMR) are reported for 32 regions of interest (ROI)s in cross-sectional studies on 57 patients with clinically diagnosed Alzheimer's disease (AD) and 20 neurologically normal controls, and in serial studies on 13 of the AD cases, including a familial, young-onset case where the diagnosis has been confirmed at autopsy. Extensive psychological testing was done on all the AD cases. Almost all cortical regions showed a significant decline in LCMR with age in the control subjects. There were the expected cortical metabolic deficits in AD and the serial studies showed a general increase in such deficits over time in 12 of the 13 cases. The regions showing the greatest declines with time in serial studies are the same as those showing the most severe deficiencies in cross-sectional studies. The young-onset case did not show a greater rate of metabolic decline than many of the older cases studied. Results on individual psychological tests tended to correlate with metabolic rates in multiple, rather than single, cortical regions, suggesting intact neuronal networks are required for good performance. The correlations with cortical metabolic activity found were of a sign indicating that the higher the metabolic rates and the better the left:right asymmetry index, the better was the performance.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 1 , February 1990 , pp. 1 - 11
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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