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Zinc changes in blood and urine during cyclic pareteral nutrition: relationships with amino acid metabolism

Published online by Cambridge University Press:  06 August 2007

H. Faure ,
X. Leverve ,
J. Arnaud ,
C. Boujet  and
A. Favier
H. Faure
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
X. Leverve
Affiliation:
Unit of Parenteral Nutrition, University Hospital, 38043 Grenoble Cedex 09, France
J. Arnaud
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
C. Boujet
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
A. Favier
Affiliation:
Laboratory of Biochemistry C, University Hospital, 38043 Grenoble Cedex 09, France
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Abstract

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Serum Zn, ultrafiltrable Zn and amino acids in serum and urine samples of twenty-seven patients receiving cyclic (12 h/24 h) parenteral nutrition were measured. These samples were collected in patients after a 12 h period of parenteral nutrition, and in the evening after 12 h without parenteral nutrition. The same determinations were performed in ten control subjects who followed the same sampling scheme. Total serum ultrafiltrable Zn showed no significant variations in the patients during parenteral nutrition, and was not significantly different in the two groups although the proportion of the Zn present in the ultrafiltrable fraction was elevated. Serum cystine levels were significantly higher (P = 0·05) in the patients than the control subjects, and cystine excretion was also higher in patients (P < 0·05) and increased after parenteral nutrition (56·0 (SE 6·5) v. 147·1 (SE 20·6) m/12 h; P < 0·001). Histidine levels did not vary significantly in serum after parenteral nutrition and were not different in the patients in comparison with the control subjects. Histidine excretion was not different in the two groups but increased significantly during parenteral nutrition (P < 0·05). Serum albumin was significantly depressed in the patients compared with the control subjects (45·3 (SE 1·5) v. 33·9 (SE 1·5) g/l; P < 0·001). These results suggest that cystine infusion and excretion relate to the changes occurring in serum Zn and in urinary Zn excretion.

Keywords

ZincParenteral nutritionAmino acids
Type
Zinc and amino acid interactions in parenteral nutrition
Information
British Journal of Nutrition , Volume 72 , Issue 5 , November 1994 , pp. 763 - 773
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Abu Hamdam, D. K., Migdal, S. D., Whitehouse, R., Rabbani, P., Prasad, A. S. & MacDonald, F. D. (1981) Renal handling of zinc: effect of cysteine infusion. American Journal of Physiology 214, F487–F494.Google Scholar
Arakawa, T., Tamura, Y. & Igarashi, Y. (1976) Zinc deficiency in two infants during total parenteral nutrition for diarrhea. American Journal of Clinical Nutrition 29, 198–204.CrossRefGoogle ScholarPubMed
Bartels, H., Böhmer, M. & Heterli, C. (1972) Serum kreatininbestimmung ohne enteiweissen (Serum creatinine determination without protein precipitation). Clinica Chimica Acta 37, 193–197.CrossRefGoogle Scholar
Bobilya, D. J., Briske-Anderson, M. & Reeves, P. G. (1993) Ligands influence Zn transport into cultured endothelial cells. Proceedings of the Society for Experimental Biology and Medicine 202, 159–166.CrossRefGoogle ScholarPubMed
Boyett, J. D. & Sullivan, J. F. (1970) Distribution of protein bound zinc in normal and cirrhotic serum. Metabolism 19, 148–157.CrossRefGoogle ScholarPubMed
Bremer, H. J., Duran, H. G. & Kamerling, J. P. (1981) Disturbances of Amino Acid Metabolism: Clinical Chemistry and Diagnosis, pp 48–49. Baltimore: Urban-Schwartzenberg.Google Scholar
Brigham, M. P., Stein, W. H. & Moore, S. (1960) The concentrations of cysteine and cystine in human blood plasma. Journal of Clinical Investigation 39, 1633–1638.CrossRefGoogle ScholarPubMed
Chappuis, P., Arnaud, J., Jaudon, M. C., Zawislak, R. & Bellanger, J. (1991) Concentration de Zn, Cu, Se, et Al dans les solutés nutritifs utilisés par voie parentérale (Concentrations of zinc, copper, selenium, and aluminium in parenteral nutritive solutions). Annales de Biologie Clinique 49, 421–427.Google Scholar
Cunningham, J. J., Lydon, M. K., Briggs, S. E. & DeCheke, M. (1991) Zinc and copper status of severely burned children during TPN. Journal of the American College of Nutrition 10, 57–62.CrossRefGoogle ScholarPubMed
Doumas, B. T., ArdWatson, W. Watson, W. & Biggs, H. G. (1971) Albumin standards and the measurement of serum albumin with bromocresol green. Clinica Chimica Acta 31, 87–96.CrossRefGoogle Scholar
Faure, H., Favier, A., Tripier, M. & Arnaud, J. (1990) Determination of the major zinc fractions in human serum by ultrafiltration. Biological Trace Element Research 24, 25–37.CrossRefGoogle ScholarPubMed
Foote, J. W. & Delves, H. T. (1984) Distribution of zinc amongst human serum globulins determined by gel filtration-affinity chromatography and atomic absorption spectrophotometry. Analyst 109, 709–711.CrossRefGoogle ScholarPubMed
Freeman, J. B., Stegink, L. D., Meyer, P. D., Fry, L. K. & DenBesten, L. (1975) Excessive urinary zinc losses during parenteral nutrition. Journal of Surgical Research 18, 463–469.CrossRefGoogle Scholar
Hambidge, K. M., Goodall, M. J., Stall, C. & Pritts, J. (1989) Post-prandial and daily changes in plasma zinc. Journal of Trace Elements and Electrolytes in Health and Diseases 3, 55–57.Google ScholarPubMed
Harris, W. R. & Keen, C. (1989) Calculations of the distribution of zinc in a computer model of human serum. Journal of Nutrition 119, 1677–1682.CrossRefGoogle Scholar
Kay, R. G. & Tasman-Jones, C. (1975) Zinc deficiency and intravenous feeding. Lancet ii, 605–606.CrossRefGoogle Scholar
Malloy, M., Rassin, D. K. & Gaull, G. E. (1981) A method for measurement of free and bound plasma cysteine. Analytical Biochemistry 113, 407–415.CrossRefGoogle Scholar
Messing, B., Poitras, P. & Bernier, J. J. (1977) Zinc deficiency in total parenteral nutrition. Lancet ii, 97–98.CrossRefGoogle Scholar
Mosebach, K.-O., Stoeckel, H., Caspari, R., M¨ller, R., Schulte, J., Lippoldt, R. & Prahl, M. (1980) Pharmacokinetic evaluation of a new maintenance solution for severely injured patients. Journal of Parenteral and Enteral Nutrition 4, 346–350.CrossRefGoogle ScholarPubMed
Pories, W. L., Henzel, J. H., Rob, C. G. & Strain, W. H. (1967) Acceleration of wound healing in man with zinc sulphate given by mouth. Lancet i, 121–124.CrossRefGoogle Scholar
Riordan, J. F. (1976) Biochemistry of zinc. Medical Clinics of North America 60, 661–674.Google Scholar
Shulman, R. J. (1989) Zinc and copper balance studies in infants receiving total parenteral nutrition. American Journal of Clinical Nutrition 49, 879–883.CrossRefGoogle ScholarPubMed
Sokal, R. R. & Rohlf, F. J. (1981) Single classification goodness of fit tests. In Biometry, pp. 716–721 [Wilson, J. and Cotter, S., editors]. New York: W. H.Freeman.Google Scholar
Solomons, N. W., Rosenberg, I. H. & Sandstead, H. (1976) Zinc deficiency in Crohn's disease. Digestion 16, 87–95.CrossRefGoogle Scholar
Strobel, C., Byrne, W. J., Abramovitz, W. & Ament, M. E. (1978) A zinc deficiency dermatitis in patients on total parenteral nutrition. International Journal of Dermatology 17, 575–581.Google Scholar
Takagi, Y., Okada, A., Itakura, T. & Kawashima, Y. (1986) Clinical studies on zinc metabolism during total parenteral nutrition as related to zinc deficiency. Journal of Parenteral and Enteral Nutrition 10, 195–202.CrossRefGoogle ScholarPubMed
Wolman, S. L., Anderson, G. H., Marliss, E. B. & Jeejeebhoy, K. H. (1979) Zinc in total parenteral nutrition: requirements and metabolic effects. Gastroenterology 76, 458–467.CrossRefGoogle ScholarPubMed
Yunice, A. A., King, R. W., Kraikitpanitch, S., Haygood, C. C. & Lindeman, R. D. (1978) Urinary zinc excretion following infusion of zinc sulfate, cysteine, histidine or glycine. American Journal of Physiology 235, F40–F45.Google ScholarPubMed
Zlotkin, S. H. (1989) Nutrient interactions with total parenteral nutrition: effects of histidine and cysteine intake on urinary zinc excretion. Journal of Pediatrics 114, 859–864.CrossRefGoogle ScholarPubMed