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Soyabean protein hydrolysate prevents the development of hypertension in spontaneously hypertensive rats

Published online by Cambridge University Press:  09 March 2007

Hsin-Yi Yang ,
Suh-Ching Yang ,
Jiun-Rong Chen ,
Ya-Hui Tzeng  and
Bor-Cheng Han
Hsin-Yi Yang
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Suh-Ching Yang
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Jiun-Rong Chen*
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Ya-Hui Tzeng
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Bor-Cheng Han
Affiliation:
School of Public Health, Taipei Medical University, Taipei 110, Taiwan
*
*Corresponding author: fax +886 2 2737 3112, Email syunei@tmu.edu.tw
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Abstract

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The aim of the present study was to investigate the anti-hypertensive and angiotensin-converting enzyme (ACE) inhibition effects of soyabean protein hydrolysate in spontaneously hypertensive rats (SHR). Soyabean protein hydrolysate was prepared by peptic hydrolysis and was added into the feed of SHR (0 % for the S0 group, 0·5 % for the S1 group, and 1 % for the S2 group) for 12 weeks. Systolic blood pressure and mean blood pressure of the S1 (164·3 (sem 4·7); 128·0 (sem 5·0) mmHg) and S2 (156·8 (sem 1·6); 120·8 (sem 3·4) mmHg) groups were significantly lower than those of the S0 group (199·4 (sem 5·2); 158·3 (sem 7·0) mmHg) at the end of the study. In the analysis of ACE activity, plasma and heart ACE activities of the S1 and S2 groups were significantly lower than those of the S0 group, and there were no significant differences in aorta, kidney, and lung ACE activities among all SHR. Soyabean protein hydrolysate had no significant effect on plasma lipids, electrolytes, or on left ventricular wall or aorta wall thickness. The results suggest that the long-term administration of soyabean protein hydrolysate might retard the development of hypertension in SHR by its inhibitory effect on ACE in vivo.

Keywords

HypertensionSoyabean proteinAngiotensin-converting enzymeSpontaneously hypertensive ratsBlood pressure
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue 3 , September 2004 , pp. 507 - 512
Copyright
Copyright © The Nutrition Society 2004

References

Astawan, M, Wahyuni, M, Yasuhara, T, Yamada, K, Tadokoro, T & Maekawa, AEffects of angiotensin I-converting enzyme inhibitory substances derived from Indonesian dried-salted fish on blood pressure of rats. Biosci Biotechnol Biochem (1995) 59, 425–429.CrossRefGoogle ScholarPubMed
Cabassi, A, Vinci, S, Cantoni, AM, Quartieri, F, Moschini, L, Cavazzini, S, Cavatorta, A & Borghetti, ASympathetic activation in adipose tissue and skeletal muscle of hypertensive rats. Hypertension (2002) 39, 656–661.CrossRefGoogle ScholarPubMed
Chen, JR, Okada, T, Muramoto, K, Suetsuna, K & Yang, SCIdentification of angiotensin I-converting enzyme inhibitory peptides derived from the peptic digest of soybean protein. J Food Biochem (2002) 26, 543–544.CrossRefGoogle Scholar
Chen, JR, Yang, SC, Suetsuna, K & Chao, CJSoybean protein-derived hydrolysate affects blood pressure in spontaneously hypertensive rats. J Food Biochem (2004) 28, 61–73.CrossRefGoogle Scholar
Cheung, HS, Wang, FL, Ondetti, MA, Sabo, EF & Cushman, DWBinding of peptide substrates and inhibitors of angiotensin-converting enzyme. J Biol Chem (1980) 255, 401–407.CrossRefGoogle ScholarPubMed
Cleland, JGF (editor) The Clinicians Guide to ACE Inhibition. 37–75. New York: Churchill Livingstone Inc. (1993)Google Scholar
Das, M, Soffers, RSPulmonary angiotensin-converting enzyme. J Biol Chem (1975) 250, 6762–6768.CrossRefGoogle ScholarPubMed
Demonty, I, Lamarche, B & Jones, PJRole of isoflavones in the hypocholesterolemic effect of soy. Nutr Rev (2003) 61, 189–203.CrossRefGoogle ScholarPubMed
Ferrier, KE, Muhlmann, MH, Baguet, JP, Cameron, JD, Jennings, GL, Dart, AM & Kingwell, BAIntensive cholesterol reduction lowers blood pressure and large artery stiffness in isolated systolic hypertension. J Am Coll Card (2002) 39, 1020–1025.CrossRefGoogle ScholarPubMed
Kagan, A, Harris, BR & Winkelstein, WEpidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: demographic, physical, dietary and biochemical characteristics. J Chronic Dis (1974) 27, 345–364.CrossRefGoogle ScholarPubMed
Karaki, H, Doi, K, Sugano, S, Uchiwa, H, Sugai, R, Murakami, U & Takemoto, SAntihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats. Comp Biochem Physiol (1990) 96, 367–371.Google ScholarPubMed
Katoh, M, Ohmachi, Y, Kurosawa, Y, Yoneda, H, Tanaka, N & Narita, HEffects of imidapril and captopril on streptozotocin-induced diabetic nephropathy in mice. Eur J Pharmacol (2000) 398, 381–387.CrossRefGoogle ScholarPubMed
Kawasaki, T, Seki, E, Osajima, K, Yoshida, M, Asada, K, Matsui, T & Osajima, YAntihypertenisve effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolysate, on mild hypertensive subjects. J Hum Hypertens (2000) 14, 519–523.CrossRefGoogle Scholar
Lamont, LSBeta-blockers and their effects on protein metabolism and resting energy expenditure. J Cardiopulm Rehabil (1995) 15, 183–185.Google ScholarPubMed
Lowry, OH, Rosebrough, NJ, Farr, AL & Randall, RJProtein measurement with the Folin phenol reagent. J Biol Chem (1951) 193, 265–275.CrossRefGoogle ScholarPubMed
Mancia, G, Carugo, S, Grassi, G, Lanzarotti, A, Schiavina, R, Cesana, G & Sega, RPrevalence of left ventricular hypertrophy in hypertensive patients without and with blood pressure control. Hypertension (2002) 39, 744–749.CrossRefGoogle ScholarPubMed
Martin, DS, Breitkopf, NP, Eyster, KM & Williams, JLDietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats. Am J Physiol (2001) 281, R553–R560.Google ScholarPubMed
Martin, DS, Williams, J, Breitkopf, NP & Eyster, KMPressor responsiveness to angiotensin in soy-fed spontaneously hypertensive rats. Can J Physiol Pharmacol (2002) 80, 1180–1186.CrossRefGoogle ScholarPubMed
Martinez, RM, Gimenez, I, Lou, JM, Mayoral, JA & Alda, JOSoy isoflavonoids exhibit in vitro biological activities of loop diuretics. Am J Clin Nutr (1998) 68, 1354S–1357S.CrossRefGoogle ScholarPubMed
Masuda, O, Nakamura, Y & Takano, TAntihypertenisve peptides are present in aorta after oral administration of sour milk containing these peptides to spontaneously hypertensive rats. J Nutr (1996) 126, 3063–3068.CrossRefGoogle Scholar
Matsui, T, Li, CH, Tanaka, T, Maki, T, Osajima, Y & Matsumoto, KDepressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma. Biol Pharm Bull (2000) 23, 427–431.CrossRefGoogle Scholar
Miura, K, Daviglus, ML, Dyer, AR, Liu, K, Garside, DB, Stamler, J & Greenland, PRelationship of blood pressure to 25-year mortality due to coronary heart disease, cardiovascular diseases, and all causes in young adult men: the Chicago Heart Association Detection Project in Industry. Arch Intern Med (2001) 161, 1501–1508.CrossRefGoogle ScholarPubMed
Miyoshi, S, Ishikawa, H, Kaneko, T, Fukui, F, Tanaka, H & Maruyama, SStructures and activity of angiotensin-I-converting enzyme inhibitors in an α-zein hydrolysateh. Agric Biol Chem (1991) 55, 1313–1318.Google Scholar
Nakamura, Y, Masuda, O & Takano, TDecrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk in spontaneously hypertensive rats. Biosci Biotechnol Biochem (1996) 60, 488–489.CrossRefGoogle ScholarPubMed
Nevala, R, Vaskonen, T, Vehniäinen, J, Korpela, R & Vapaatalo, HSoy based diet attenuates the development of hypertension when compared to casein based diet in spontaneously hypertensive rat. Life Sci (2000) 66, 115–124.CrossRefGoogle ScholarPubMed
Pelsuo, MR, Winters, TA, Shanahan, MF & Banz, WJA cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipid in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats. J Nutr (2000) 130, 2333–2342.CrossRefGoogle Scholar
Saito, Y, Wanezaki, K, Kawato, A & Imayasu, SStructure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci Biotechnol Biochem (1994) 58, 1767–1771.CrossRefGoogle ScholarPubMed
Takeda, Y, Yoneda, T, Demura, M, Furukawa, K, Miyamori, I & Mabuchi, HEffects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats. J Hypertens (2001) 19, 635–639.CrossRefGoogle ScholarPubMed
Wang, MF, Yamamoto, S, Chung, HM, Chung, SY, Miyatani, S, Mori, M, Okita, T & Sugano, MAntihypercholesterolemic effect of undigested fraction of soybean protein in young female volunteers. J Nutr Sci Vitaminol (1995) 41, 187–195.CrossRefGoogle ScholarPubMed
Wu, J & Ding, XHypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soybean protein on spontaneously hypertensive rats. J Agric Food Chem (2001) 49, 501–506.CrossRefGoogle ScholarPubMed
Yamamoto, NAntihypertensive peptide derived from food proteins. Biopolymers (1997) 43, 129–134.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Yamamoto, S, Toida, I & Iwai, KRe-examination of spectrophotometric assay for serum angiotensin-converting enzyme (in Japanese). Nihon Kyobu Shikkan Gakkai Zasshi (1980) 18, 297–301.Google Scholar
Yokoyama, K, Chiba, H & Yoshikawa, MPeptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci Biotechnol Biochem (1992) 56, 1541–1545.CrossRefGoogle ScholarPubMed
Yusuf, S, Sleight, P, Pogue, J, Bosch, J, Davies, R & Dagenais, GEffects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators; N Eng J Med (2000) 342, 145–153.Google ScholarPubMed