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Short-lived radionuclides in nutritional physiology. A model study with l-[Me-11C]methionine in the pig

Published online by Cambridge University Press:  04 June 2009

C.-G. Stålnacke ,
B. Jones ,
B. Långström ,
H. Lundqvist ,
P. Malmborg ,
S. Sjöberg  and
B. Larsson
C.-G. Stålnacke
Affiliation:
Department of Physical Biology, Gustaf Werner Institute, University of Uppsala, Box 531, S-751 21 Uppsala, Sweden
B. Jones
Affiliation:
Department of Clinical Chemistry, Clinical Centre, College of Veterinary Medicine, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden
B. Långström
Affiliation:
Department of Organic Chemistry, University of Uppsala, Box 531, S-751 21 Uppsala, Sweden
H. Lundqvist
Affiliation:
Department of Physical Biology, Gustaf Werner Institute, University of Uppsala, Box 531, S-751 21 Uppsala, Sweden
P. Malmborg
Affiliation:
Department of Physical Biology, Gustaf Werner Institute, University of Uppsala, Box 531, S-751 21 Uppsala, Sweden
S. Sjöberg
Affiliation:
Department of Organic Chemistry, University of Uppsala, Box 531, S-751 21 Uppsala, Sweden
B. Larsson
Affiliation:
Department of Physical Biology, Gustaf Werner Institute, University of Uppsala, Box 531, S-751 21 Uppsala, Sweden
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Abstract

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1. A‘new’carbon radioisotope, 11C, for use in nutritional studies is presented. It has a 20 min half-life, and decays by positron emission giving annihilation photons of 511 keV energy (Wolf & Redvanly. 1977). Thus repeated studies can be made with short time intervals and the distribution of radioactivity in the experimental animal can be detected externally.

2. 11C was produced with a tandem Van de Graaff accelerator and L-[Me-11C]methionine was synthesized and used in model experiments in the pig. The tracer wasadministered intravenously through a catheter in the jugular vein of pigs weighing between 40 and 100 kg. In a series of experiments, one pig received a low-melhionine diet supplemented with DL-methionine to give three different levels of methioninc intake.

3. The radioactivity distribution between liver and muscle was measured as a function of time by external detectors for 2–3 h after administration. Blood and exhaled CO2 were sampled and measured for radioactivity.

4. The results indicate that 11C is a useful radionuclide in nutritional studies in intact large domestic animals.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 47 , Issue 3 , May 1982 , pp. 537 - 545
Copyright
Copyright © The Nutrition Society 1982

References

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