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Metabolic responses to low doses of cyanocobalamin in patients with megaloblastic anaemia

Published online by Cambridge University Press:  09 March 2007

J. F. Adams ,
R. Hume ,
Elizabeth H. Kennedy ,
T. G. Pirrie ,
J. W. Whitelaw  and
A. M. White
J. F. Adams
Affiliation:
Southern General Hospital, Glasgow
R. Hume
Affiliation:
Southern General Hospital, Glasgow
Elizabeth H. Kennedy
Affiliation:
Southern General Hospital, Glasgow
T. G. Pirrie
Affiliation:
Southern General Hospital, Glasgow
J. W. Whitelaw
Affiliation:
Southern General Hospital, Glasgow
A. M. White
Affiliation:
CIBA Research Laboratories, Horsham, Sussex
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Abstract

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1. The metabolic responses to daily treatment with 1 μg cyanocobalamin were studied in sixteen patients with megaloblastic anaemia due to cobalamin deficiency.

2. The fall in serum iron was sluggish in most patients. The pattern of reticulocyte responses varied widely, the most common being a plateau with suboptimal maximal value.

3. Urinary propionic acid excretion before treatment was normal in two out of six patients. A transient rise during treatment was observed in two patients, possibly owing to demands on coenzyme stores. The fall in urinary propionic acid excretion during treatment was slow.

4. Serum vitamin B12 levels rose during treatment. In two patients an abrupt rise was found, possibly owing to release of stored cobalamin into the circulation.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 4 , December 1968 , pp. 575 - 582
Copyright
Copyright © The Nutrition Society 1968

References

Adams, J. F., Glen, A. I. M., Kennedy, E. H., Mackenzie, I. L., Morrow, J. M., Anderson, J. R., Gray, K. G. & Middleton, D. G. (1964). Lancet i, 401.CrossRefGoogle Scholar
Boddy, K. & Adams, J. F. (1968). Am. J. clin. Nutr. 21, 657.CrossRefGoogle Scholar
Cox, E. V., Robertson-Smith, D., Small, M. & White, A. M. (1968). Clin. Sci. 35, 123.Google Scholar
Cox, E. V. & White, A. M. (1962). Lancet ii, 853.CrossRefGoogle Scholar
Dacie, J. V. & Lewis, S. M. (1963). Practical Haematology, 3rd ed. London: J. and A. Churchill Ltd.Google Scholar
Darby, W. J., Bridgforth, E. B., Le Brocuy, J., Clark, S. J., De Oliviera, J. D., Kevany, J., McGanity, W. J. & Perez, C. (1958). Am. J. Med. 25, 726.CrossRefGoogle Scholar
Gompertz, D., Jones, J. H. & Knowles, J. P. (1967). Lancet i, 424.CrossRefGoogle Scholar
Gottlieb, C., Lau, K-S., Wasserman, L. R. & Herbert, V. (1965). Blood 25, 875.CrossRefGoogle Scholar
Hansen, H. A. & Weinfeld, A. (1962). Acta med. scand. 172, 472.Google Scholar
Hawkins, C. F. (1955). Br. med. J. i, 383.CrossRefGoogle Scholar
Heyssel, R. M., Bozian, R. C., Darby, W. J. & Bell, M. C. (1966). Am. J. clin. Nutr. 18, 176.CrossRefGoogle Scholar
Hutner, S. H., Bach, M. K. & Ross, G. I. M. (1956). J. Protozool. 3, 101.CrossRefGoogle Scholar
Kay, A. W. (1953). Br. med. J. ii, 77.CrossRefGoogle Scholar
Kohn, J., Mollin, D. L. & Rosenbach, L. M. (1961). J. clin. Path. 14, 345.CrossRefGoogle Scholar
Marshall, R. A. & Jandl, J. H. (1960). Archs intern. Med. 105, 352.CrossRefGoogle Scholar
Ramsay, W. N. M. (1957). Clinica. chim. Acta 2, 214.CrossRefGoogle Scholar
Roe, J. H. & Rice, E. W. (1948). J. biol. Chem. 173, 507.CrossRefGoogle Scholar
Schilling, R. F. (1953). J. Lab. clin. Med. 42, 860.Google Scholar
Sullivan, L. W. & Herbert, V. (1965). New Engl. J. Med. 272, 340.CrossRefGoogle Scholar
Ungley, C. C. (1949). Br. med. J. ii, 1370.CrossRefGoogle Scholar
Varley, H. (1958). Practical Clinical Biochemistry, 2nd ed. London: Heinemann.Google Scholar
Vivacqua, R. J., Myerson, R. M., Prescott, D. J. & Rabinowitz, J. L. (1966). Am. J. med. Sci. 251, 507.CrossRefGoogle Scholar
Waters, A. W. & Mollin, D. K. (1963). Br. J. Haemat. 9, 319.CrossRefGoogle Scholar
White, A. M. (1965). Biochem. J. 95, 17PGoogle Scholar