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The interaction of vitamin A deficiency and rotavirus infection in the mouse

Published online by Cambridge University Press:  09 March 2007

Faruk Ahmed ,
David B. Jones  and
Alan A. Jackson
Faruk Ahmed
Affiliation:
Department of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO9 3TU
David B. Jones
Affiliation:
Department of Pathology, University of Southampton, Bassett Crescent East, Southampton SO9 3TU
Alan A. Jackson
Affiliation:
Department of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO9 3TU
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Abstract

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Weanling mice were fed on a control diet ad lib., a vitamin A-deficient diet ad lib. or pair-fed to the intake of the vitamin A-deficient group. Vitamin A deficiency was induced by 63–70 d of age. On day 77 mice were given 30 μl rotavirus/mouse orally and examined histologically 1 week later. There were no changes in relative liver weight in any of the groups, but following infection animals deficient in vitamin A showed a significant increase in spleen weight compared with the other groups. The relative weight of the thymus was reduced by vitamin A deficiency, in both non-infected and infected animals. The histology of the spleen, thymus and small intestine was similar in all three dietary groups before infection. The number of goblet cells per duodenal villus in vitamin A-deficient animals was significantly lower than that of control and pair-fed animals. In the small intestine of vitamin A-deficient animals, rotavirus infection caused dramatic changes to the mucosa, with almost complete destruction of the tips of the villi, but control and pair-fed animals had normal villi. It is concluded that although rotavirus infection and vitamin A-deficiency cause few changes alone, in their action together there is significant destruction of the mucosal barrier of the small intestine.

Keywords

RotavirusVitamin AMouse model
Type
Vitamins
Information
British Journal of Nutrition , Volume 63 , Issue 2 , March 1990 , pp. 363 - 373
Copyright
Copyright © The Nutrition Society 1990

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