Hostname: page-component-848d4c4894-nmvwc Total loading time: 0 Render date: 2024-07-04T03:56:36.716Z Has data issue: false hasContentIssue false
  • English
  • Français

Interaction between caffeine intake and heart zinc concentrations in the rat

Published online by Cambridge University Press:  09 March 2007

Magdalena J. Rossowska ,
Chantal Dinh ,
Sheila B. Gottschalk ,
Malektaj Yazdani ,
Fletcher S. Sutton III  and
Tetsuo Nakamoto
Magdalena J. Rossowska
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Chantal Dinh
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Sheila B. Gottschalk
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiologyand Pediatrics, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Malektaj Yazdani
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Fletcher S. Sutton III
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Tetsuo Nakamoto
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology, Louisiana State University Medical Center, New Orleans, LA 70119, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The purpose of the present study was to determine the levels of zinc in the hearts of growing post-weaning offspring, fetuses and their dams chronically fed caffeine. A further study was conducted to determine the distribution of Zn in subcellular heart fractions affected by acutely injecting caffeine into the veins of the adult rats. After delivery pups were raised on a 200 g protein/kg diet until day 22 of weaning. On day 22 randomly selected male offspring from each litter were divided into two groups. Group 1 was fed continuously on the same diet as a control, whereas in the experimental group offspring were fed on a 200 g protein/kg diet supplemented with caffeine (20 mg/kg). On day 49 the animals were killed and Zn, calcium and magnesium concentrations of the hearts were measured. In the second series of studies pregnant dams were randomly divided into two groups. Group 1 was fed on a 200 g protein/kg diet from day 3 of gestation, whereas in the experimental group dams were fed on the diet supplemented with caneme. On day 22 of gestation the fetuses were surgically removed. The Zn, Ca and Mg concentrations of hearts of fetuses and dams were determined. In the third phase a caffeine solution was injected into the vein. After 45 min the hearts were removed and Zn levels in the subcellular fractions determined. The hearts of the growing offspring fed on a caffeine-supplemented diet consistently showed decreased Zn and Ca levels compared with the non-caffeine group. In contrast, Zn and Ca concentrations of the hearts of fetuses and dams showed no difference between caffeine and non-caffeine groups. In the various fractions studied, the Zn contents affected by caffeine were in the supernatant (cytoplasmic) fraction. This fraction contained 30% of the Zn concentration of the homogenates. Current findings suggest that caffeine intake and heart Zn levels are closely correlated.

Keywords

CaffeineHeartZincRat
Type
Minerals: Absorption and Bioavailability
Information
British Journal of Nutrition , Volume 64 , Issue 2 , September 1990 , pp. 561 - 567
Copyright
Copyright © The Nutrition Society 1990

References

Bettger, W. J. & O'Dell, B. L. (1981). A critical physiological role of zinc in the structure and function of biomembranes. Life Sciences 28, 1425–1438.CrossRefGoogle ScholarPubMed
Bremner, I. (1987 a). Involvement of metallothionein in the hepatic metabolism of copper. Journal of Nutrition 117, 19–29.CrossRefGoogle ScholarPubMed
Bremner, I. (1987 b). Nutritional and physiological signifiance of metallothionein. In Metallothionein II: Proceedings of the Second International Meeting on Metallothionein and Other Low-Molecular- Weight, Metal-Binding Proteins, pp. 81–107 [Kagi, J. H. R. and Kojima, Y., editors]. Basel: Birkhauser Verlag.CrossRefGoogle Scholar
Callewaert, G., Cleemann, L. & Morad, M. (1989). Caffeine induced Ca2+ release activates Ca2+ extrusion via Na+-Ca2+ exchanger in cardiac myocytes. American Journal of Physiology 257, C147–C152.CrossRefGoogle ScholarPubMed
Cassens, R. G., Hoekstra, W. G., Faltin, E. C. & Briskey, E. J. (1967). Zinc content and subcellular distribution in red vs white porcine skeletal muscle. American Journal of Physiology 212, 688–692.CrossRefGoogle ScholarPubMed
Cousins, R. J. (1985). Absorption, transport and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiological Reviews 65, 238–309.CrossRefGoogle ScholarPubMed
Dreosti, I. E. (1982). Zinc in prenatal development. In Current Topics in Nutrition and Disease; Clinical Applications of Recent Advances in Zinc Metabolism, vol.7, pp. 19–38 [Prasad, A. S., Dreosti, I. E., and Hetzel, B. S., editors]. New York: Alan Liss.Google Scholar
Dunn, M. A., Blalock, T. L. & Cousins, R. J. (1987). Metallothionein. Proceeding of the Society for Experimental Biology and Medicine 185, 107–109.CrossRefGoogle ScholarPubMed
Fiske, C. H. & Subbarow, Y. (1925). The colorimetric determination of phosphorus. Journal of Biological Chemistry 66, 375–400.CrossRefGoogle Scholar
Fleet, J. C., Qureshi, M. A., Dietert, R. R. & McCormick, C. C. (1988). Tissue-specific accumulation of metallothionein in chicken as influenced by the route of zinc administration. Journal of Nutrition 117, 481–489.Google Scholar
Hamer, D. H. (1986). Metallothionein. Annual Review of Biochemistry 55, 913–951.CrossRefGoogle ScholarPubMed
Harvey, W. K. & Nakamoto, T. (1988). The infuence of a high-protein low carbohydrate diet on bone development in the fetuses of rat dams with streptozotocin-induced diabetes. British Journal of Nutrition 53, 57–62.CrossRefGoogle Scholar
Jiritano, L., Bortolotti, A., Gastari, F. & Botani, M. (1985). Caffeine disposition after oral administration to pregnant rats. Xenobiotica 15, 1045–1051.CrossRefGoogle ScholarPubMed
Johansson, S. (1981). Cardiovascular lesions in Sprague-Dawley rats induced by long-term treatment with caffeine. Acta Pathologica et Microbiologica Scandinavica A89, 185–191.Google Scholar
Jones, L. R., Besch, M. R. Jr, Fleming, J. W., McConnaughey, M. M. & Watanabe, A. M. (1979). Separation of vesicles of cardiac sarcolemma from vesicles of cardiac sarcoplasmic reticulum. Journal of Biological Chemistry 254, 530–539.CrossRefGoogle ScholarPubMed
Kithas, P. A., Artman, M., Thompson, W. J. & Strada, S. J. (1989). Subcellular distribution of high-affinity type IV cyclic AMP phosphodiesterase activities in rabbit ventricular myocardium: relations to post-natal maturation. Journal of Molecular and Cellular Cardiology 21, 507–517.CrossRefGoogle ScholarPubMed
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–275.CrossRefGoogle ScholarPubMed
Muneoka, Y., Twarog, B. M. & Kanno, Y. (1979). The effect of zinc ion on the mechanical responses of Mytilus smooth muscle. Comparative Biochemistry and Physiology 62C, 35–40.Google ScholarPubMed
Nakamoto, T. & Shaye, R. (1986). Protein- energy malnutrition in rats during pregnancy modifies the effects of caffeine on fetal bones. Journal of Nutrition 116, 633–640.CrossRefGoogle ScholarPubMed
Nowak, T. S. & Munro, H. N. (1977). Nutrition and the Brain, pp. 193–260. New York: Raven Press.Google Scholar
Ohnishi, A., Branch, R. A., Jackson, K., Hamilton, R., Biaggioni, I., Deray, G. & Jackson, E. K. (1986). Chronic caffeine administration exacerbates renovascular, but not genetic, hypertension in rats. Journal of Clinical Investigation 78, 1045–1050.CrossRefGoogle Scholar
Pasternak, C. A. (1988). A novel role of Ca and Zn: protection of cells against membrane damage. Bioscience Reports 8, 579–583.CrossRefGoogle Scholar
Quist, E., Satumtira, N. & Powell, P. (1989). Regulation of polyphosphoinositide synthesis in cardiac membrane. Archives of Biochemistry and Biophysics 271, 21–32.CrossRefGoogle Scholar
Richards, M. P. (1989). Recent developments in trace element metabolism and function: role of metallothionein in copper and zinc metabolism. Journal of Nutrition 119, 1062–1070.CrossRefGoogle ScholarPubMed
Richards, M. P. & Cousins, R. J. (1975). Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis. Biochemical and Biophysical Research Communications 64, 1215–1223.CrossRefGoogle ScholarPubMed
Richards, M. P. & Cousins, R. J. (1977). Isolation of an intestinal metallothionein induced by parenteral zinc. Biochemical and Biophysical Research Communications 75, 286–293.CrossRefGoogle ScholarPubMed
Rossowska, M. J. & Nakamoto, T. (1990). Effect of caffeine on zinc absorption and Zn concentration in rat tissue. British Journal of Nutrition 64, 553–559.CrossRefGoogle ScholarPubMed
Rousseau, E. & Meissner, G. (1989). Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine. American Journal of Physiology 556, H328–H333.Google Scholar
Rubtsov, A. M. & Murphy, A. J. (1988). Caffeine interaction with the Ca-release of heavy sarcoplasmic reticulum. Evidence that 170 kD Ca-binding protein is a caffeine receptor of the Ca channels. Biochemical and Biophysical Research Communications 154, 462–468.CrossRefGoogle ScholarPubMed
Smeyers-Verbeke, J., May, C., Drochmans, P. & Massart, D. L. (1977). The determination of Cu, Zn and Mn in subcellular rat liver fractions. Analytical Biochemistry 83, 746–753.CrossRefGoogle ScholarPubMed
Speich, M. (1982). Concentrations of lead, cadmium and zinc in human heart muscle and aorta after acute myocardial infarction. Journal of the American College of Nutrition 1, 255–262.CrossRefGoogle ScholarPubMed
Temples, T. E., Geoffray, D. J., Nakamoto, T., Hartman, A. D. & Miller, H. I. (1985). Effects of chronic caffeine injection on growth and myocardial function. Proceedings of the Society for Experimental Biology and Medicine 179, 388–395.CrossRefGoogle Scholar
Temples, T. E., Geoffray, D. J., Nakamoto, T., Hartman, A. D. & Miller, H. I. (1987). Effect of chronic caffeine intake on myocardial function during early growth. Pediatric Research 21, 391–395.CrossRefGoogle ScholarPubMed
Vuori, E., Salmela, S., AkerblomH, K. H, K., Vikari, J., Uhari, M., Suoninen, P., Pietikainen, M., Pesonen, E., Lahde, P. L. & Dhari, P. (1985). Atherosclerosis precursors in Finnish children and adolescents. XIII. Serum and hair copper and zinc concentrations. Acta Paediatrica Scandinavica 318, Suppl., 205–212.CrossRefGoogle ScholarPubMed
Webb, M. (1972). Protection by zinc against cadmium toxicity. Biochemical Pharmacology 21, 2767–2772.CrossRefGoogle ScholarPubMed
Winick, M. & Noble, A. (1965). Quantitative changes in DNA, RNA and protein during prenatal and postnatal growth in the rat. Developmental Biology 12, 451–466.CrossRefGoogle ScholarPubMed
Zeman, F. J. (1970). Effect of protein deficiency during gestation on postnatal cellular development in the young rat. Journal of Nutrition 100, 530–538.CrossRefGoogle ScholarPubMed